(E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

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Chemical Name:(E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one
CAS No.:1429786-08-2
Molecular Formula:C₂₉H₃₄N₆O₃
Molecular Weight:514.627
Hs Code.:

Synonyms:(E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

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Chemical Property of (E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

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Technology Process of (E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

There total 8 articles about (E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 212960-17-3
(±)-1-(1-propyl-2(1H)-phthalazinyl)-2-propen-1-one

: 1429786-01-5
5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidine-2,4-diamine

: 1429786-08-2
(E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

Guidance literature:: With 1-ethyl-piperidine; palladium diacetate; In N,N-dimethyl-formamide; at 140 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201200291

Reference yield:

: 1429785-97-6
2-amino-5-(3-iodo-4,5-dimethoxybenzyl)-6-ethylpyrimidin-4-ol

: 1429786-08-2
(E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 106 °C / Cooling with ice

2: ammonia / ethanol / 16 h / 0 - 165 °C / Inert atmosphere

3: palladium diacetate; 1-ethyl-piperidine / N,N-dimethyl-formamide / 140 °C / Inert atmosphere

With 1-ethyl-piperidine; ammonia; palladium diacetate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200291

Reference yield:

: 32024-15-0
3,4-dimethoxy-5-iodobenzaldehyde

: 1429786-08-2
(E)-3-(5-((2,4-diamino-6-ethylpyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(propyl-phthalazin-2(1H)-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 0.83 h / 23 °C / Inert atmosphere

2.1: phosphorus tribromide / diethyl ether / 0.83 h / 0 - 23 °C / Inert atmosphere

3.1: sodium methylate / ethanol / 50 °C / Inert atmosphere

3.2: 78 °C / Inert atmosphere

4.1: sodium methylate / ethanol / 0 - 78 °C / Inert atmosphere

4.2: 0 °C

5.1: trichlorophosphate / 106 °C / Cooling with ice

6.1: ammonia / ethanol / 16 h / 0 - 165 °C / Inert atmosphere

7.1: palladium diacetate; 1-ethyl-piperidine / N,N-dimethyl-formamide / 140 °C / Inert atmosphere

With 1-ethyl-piperidine; sodium tetrahydroborate; ammonia; sodium methylate; palladium diacetate; phosphorus tribromide; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200291