2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

Base Information

Chemical Name:2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate
CAS No.:1602492-14-7
Molecular Formula:C₁₉H₁₆F₄N₂O₃
Molecular Weight:396.341
Hs Code.:

Synonyms:2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

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Chemical Property of 2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

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Technology Process of 2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

There total 5 articles about 2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 602309-42-2
4-chlorophenyl 3-(2,4-difluorophenyl)-3-oxopropanimidothioate hydrochloride

: 1151805-32-1
2-(4-amino-3,5-difluorophenyl)ethanol

: 108-24-7
acetic anhydride

: 1602492-14-7
2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

Guidance literature:: 4-chlorophenyl 3-(2,4-difluorophenyl)-3-oxopropanimidothioate hydrochloride; 2-(4-amino-3,5-difluorophenyl)ethanol; With acetic acid; at 80 ℃; for 2.5h;

acetic anhydride; at 80 ℃; for 0.75h;

Reference yield:

: 19064-24-5
2,6-difluoro-1-nitrobenzene

: 1602492-14-7
2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.5 h / -35 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3.33 h / 0 - 20 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 16.33 h / 0 - 20 °C / Inert atmosphere

3.2: 0 °C

4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 40 h / 20 °C / Inert atmosphere

5.1: acetic acid / 2.5 h / 80 °C

5.2: 0.75 h / 80 °C

With dimethylsulfide borane complex; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 288580-60-9
tert-butyl (3,5-difluoro-4-nitrophenyl)acetate

: 1602492-14-7
2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 3.33 h / 0 - 20 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 16.33 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 40 h / 20 °C / Inert atmosphere

4.1: acetic acid / 2.5 h / 80 °C

4.2: 0.75 h / 80 °C

With dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate;