2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

Base Information

Chemical Name:2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate
CAS No.:1151805-63-8
Molecular Formula:C₂₂H₁₆F₄N₂O₄
Molecular Weight:448.374
Hs Code.:

Synonyms:2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

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Chemical Property of 2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

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Technology Process of 2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

There total 8 articles about 2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1151805-62-7
2-(4-{[1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-3,5-difluoro-phenyl)ethyl acetate

: 471-25-0
Propiolic acid

: 1151805-63-8
2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

Guidance literature:: Propiolic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

2-(4-{[1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-3,5-difluoro-phenyl)ethyl acetate; In tetrahydrofuran; at 80 ℃; for 5h;

Reference yield: 37.0%

: 1151805-62-7
2-(4-{[1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-3,5-difluoro-phenyl)ethyl acetate

: 530-62-1
1,1'-carbonyldiimidazole

: 471-25-0
Propiolic acid

: 1151805-63-8
2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

Guidance literature:: 1,1'-carbonyldiimidazole; Propiolic acid; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

2-(4-{[1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-3,5-difluoro-phenyl)ethyl acetate; In tetrahydrofuran; at 20 - 80 ℃; Inert atmosphere;

Reference yield: 28.0%

: 1602492-14-7
2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate

: 471-25-0
Propiolic acid

: 1151805-63-8
2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl acetate

Guidance literature:: Propiolic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

2-(4-{[3-(2,4-difluorophenyl)-3-oxopropanimidoyl]amino}-3,5-difluorophenyl)ethyl acetate; In tetrahydrofuran; Reflux;