2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide

Base Information

• Chemical Name: 2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide
• CAS No.: 391903-22-3
• Molecular Formula: C₂₄H₂₁N₅O₃
• Molecular Weight: 427.462
• Mol file: 391903-22-3.mol

Synonyms:2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide

Chemical Property of 2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide

There total 12 articles about 2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dinitrobenzoic acid (528-45-0) → 2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide (391903-22-3)

Guidance literature:

Multi-step reaction with 8 steps

1: thionyl chloride / 12 h / 80 °C

2: 20.3 g / pyridine / CH₂Cl₂ / 20 °C

3: hydrogen / 5 percent Pd/C / ethanol / 3 h / 20 °C

4: 1.95 g / sodium pyrosulfite / ethanol; H₂O / 4 h / Heating

5: 88 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 6 h

6: 71 percent / sodium pyrosulfite / ethanol; H₂O / Heating

7: thionyl chloride / 4 h / 80 °C

8: 560 mg / pyridine / CH₂Cl₂ / 24 h / 20 °C

With pyridine; sodium disulfite; lithium aluminium tetrahydride; thionyl chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/S0968-0896(01)00170-5

Reference yield:

3,4-dinitrobenzoyl chloride (24376-18-9) → 2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide (391903-22-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 20.3 g / pyridine / CH₂Cl₂ / 20 °C

2: hydrogen / 5 percent Pd/C / ethanol / 3 h / 20 °C

3: 1.95 g / sodium pyrosulfite / ethanol; H₂O / 4 h / Heating

4: 88 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 6 h

5: 71 percent / sodium pyrosulfite / ethanol; H₂O / Heating

6: thionyl chloride / 4 h / 80 °C

7: 560 mg / pyridine / CH₂Cl₂ / 24 h / 20 °C

With pyridine; sodium disulfite; lithium aluminium tetrahydride; thionyl chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/S0968-0896(01)00170-5

Reference yield:

N-methoxy N-methyl 3,4-dinitrobenzoic acid amide (391903-19-8) → 2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzoimidazole)-6-carboxylic acid methoxy-methyl amide (391903-22-3)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogen / 5 percent Pd/C / ethanol / 3 h / 20 °C

2: 1.95 g / sodium pyrosulfite / ethanol; H₂O / 4 h / Heating

3: 88 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 6 h

4: 71 percent / sodium pyrosulfite / ethanol; H₂O / Heating

5: thionyl chloride / 4 h / 80 °C

6: 560 mg / pyridine / CH₂Cl₂ / 24 h / 20 °C

With pyridine; sodium disulfite; lithium aluminium tetrahydride; thionyl chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/S0968-0896(01)00170-5

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

3,4-dinitrobenzoic acid

ethyl 3,4-diaminobenzoate

3,4-dinitrobenzoyl chloride

Downstream raw materials:

2'-(4-methoxy-phenyl)-[2,6'] bis(1H-benzimidazole)-6-carbaldehyde