4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole

Base Information

Chemical Name:4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole
CAS No.:1373440-46-0
Molecular Formula:C₂₄H₂₈N₂O₂S
Molecular Weight:408.565
Hs Code.:

Synonyms:4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole

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Chemical Property of 4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole

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Technology Process of 4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole

There total 4 articles about 4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1373440-43-7
benzyl (1R,3S)-3-(4-tert-butyl-1,3-thiazol-2-yl)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

: 1373440-46-0
4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole

Guidance literature:: With propyl sulfide; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 3.5h; Inert atmosphere;

Reference yield:

: 1240163-16-9
(1R,3S)-2-(benzyloxycarbonyl)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 1373440-46-0
4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

2: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C

3: calcium carbonate / methanol / Reflux

4: propyl sulfide; boron trifluoride diethyl etherate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

With Lawessons reagent; pyridine; propyl sulfide; di-tert-butyl dicarbonate; boron trifluoride diethyl etherate; ammonium bicarbonate; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1373440-40-4
benzyl (1R,3S)-3-carbamoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

: 1373440-46-0
4-tert-butyl-2-((1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C

2: calcium carbonate / methanol / Reflux

3: propyl sulfide; boron trifluoride diethyl etherate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

With Lawessons reagent; propyl sulfide; boron trifluoride diethyl etherate; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane;