sulfamylbutyric acid benzyl ester

Base Information

• Chemical Name: sulfamylbutyric acid benzyl ester
• CAS No.: 1034774-65-6
• Molecular Formula: C₁₁H₁₅NO₄S
• Molecular Weight: 257.31
• Mol file: 1034774-65-6.mol

Synonyms:sulfamylbutyric acid benzyl ester

Chemical Property of sulfamylbutyric acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of sulfamylbutyric acid benzyl ester

There total 2 articles about sulfamylbutyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

benzyl bromide (100-39-0) + 3-carboxypropane sulfonamide (175476-52-5) → sulfamylbutyric acid benzyl ester (1034774-65-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1039/c2cc15911b

Reference yield: 41.0%

→ sulfamylbutyric acid benzyl ester (1034774-65-6)

Guidance literature:

With sodium sulfite; In water; Reflux;

With thionyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 70 ℃; for 1h;

With ammonium hydroxide; In acetonitrile; at 0 ℃; for 0.333333h;

Reference yield: 57.0%

sulfamylbutyric acid benzyl ester (1034774-65-6) + N-(9-fluorenylmethoxycarbonyl)-D-leucine (35661-60-0,126727-03-5,114360-54-2) → Fmoc-D-Leu-sulfamoylbutylic acid benzylester

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 - 20 ℃;

DOI:10.1002/anie.201805541

upstream raw materials:

benzyl bromide

3-carboxypropane sulfonamide

Downstream raw materials:

C₂₉H₃₀N₂O₇S