ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt

Base Information

Chemical Name:ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt
CAS No.:1204820-76-7
Molecular Formula:C₈H₁₃NO₂*C₁₈H₁₄O₈
Molecular Weight:513.501
Hs Code.:

Synonyms:ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt

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Chemical Property of ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt

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Technology Process of ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt

There total 1 articles about ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17026-42-5
O,O'-dibenzoyl-D-tartaric acid

: 63618-09-7
(R)-3-azabicyclo[3.1.0]hexane-1-carboxylic acid ethyl ester

: 1204820-76-7
ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt

Guidance literature:: In methanol; at 20 ℃; Reflux; Inert atmosphere;

Reference yield: 6.38%

: 414910-03-5
(2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide

: 1204820-76-7
ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt

: 1204820-77-8
ethyl (1R,5R)-3-[(2R,4R)-1-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-piperidinyl]-3-azabicyclo[3.1.0]hexane-1-carboxylate

: 1204820-78-9
ethyl (1R,5R)-3-[(2R,4S)-1-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-piperidinyl]-3-azabicyclo[3.1.0]hexane-1-carboxylate

Guidance literature:: ethyl (1R,5R)-3-azabicyclo[3.1.0]hexane-1-carboxylate (2S,3S)-2,3-bis[(phenylcarbonyl)oxy]butanedioic acid salt; With triethylamine; In methanol; at 25 ℃; for 0.75h; Inert atmosphere;

(2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide; In methanol; at 20 ℃; for 2h;

With methanol; sodium cyanoborohydride; at 20 ℃;