3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H₅]phenyl]butan-2R-ol

Base Information

• Chemical Name: 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H₅]phenyl]butan-2R-ol
• CAS No.: 856765-77-0
• Molecular Formula: C₁₉H₃₂N₂O₃
• Molecular Weight: 341.435

Synonyms:3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H₅]phenyl]butan-2R-ol

Chemical Property of 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H₅]phenyl]butan-2R-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H₅]phenyl]butan-2R-ol

There total 5 articles about 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H₅]phenyl]butan-2R-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

isobutylamine (78-81-9) + (1S,2S)-(oxiranyl-2-[2H5]-phenyl-ethyl)-carbamic acid tert-butyl ester (856765-76-9) → 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H5]phenyl]butan-2R-ol (856765-77-0)

Guidance literature:

In isopropyl alcohol; at 86 ℃; for 4h;

DOI:10.1002/jlcr.870

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H5]phenyl]butan-2R-ol (856765-77-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: KOH / ethanol; H₂O / 2 h / 70 °C

1.2: 94 percent / ethanol; H₂O; CH₂Cl₂ / 2 h / 20 °C / pH 7

2.1: 100 percent / hydrogen / Pd/C / ethyl acetate / 18 h

3.1: 1-bromocarbonyl-1-methylethyl acetate / CHCl₃ / 3 h / 20 °C

3.2: 73 percent / NaOMe / tetrahydrofuran / 4 h / 20 °C

4.1: 100 percent / propan-2-ol / 4 h / 86 °C

With potassium hydroxide; acetoxyisobutyryl bromide; hydrogen; palladium on activated charcoal; In ethanol; chloroform; water; ethyl acetate; isopropyl alcohol;

DOI:10.1002/jlcr.870

Reference yield:

S-4-[2H5]benzyl-5S-(benzyloxymethyl)-oxazolidin-2-one (856765-73-6) → 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H5]phenyl]butan-2R-ol (856765-77-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: KOH / ethanol; H₂O / 2 h / 70 °C

1.2: 94 percent / ethanol; H₂O; CH₂Cl₂ / 2 h / 20 °C / pH 7

2.1: 100 percent / hydrogen / Pd/C / ethyl acetate / 18 h

3.1: 1-bromocarbonyl-1-methylethyl acetate / CHCl₃ / 3 h / 20 °C

3.2: 73 percent / NaOMe / tetrahydrofuran / 4 h / 20 °C

4.1: 100 percent / propan-2-ol / 4 h / 86 °C

With potassium hydroxide; acetoxyisobutyryl bromide; hydrogen; palladium on activated charcoal; In ethanol; chloroform; water; ethyl acetate; isopropyl alcohol;

DOI:10.1002/jlcr.870

upstream raw materials:

isobutylamine

(1S,2S)-(oxiranyl-2-[2H₅]-phenyl-ethyl)-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

S-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-propan-2S,3-diol

Downstream raw materials:

[{1-{1-[2H₅]phenylmethyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propylcarbamoyl}-2,2-dimethyl-propylcarbamoyl}-methyl](3-fluoro-benzyl)-carbamic acid tert-butyl ester

[(1{1-[2H₅]phenylmethyl-2-hydroxy-3-[isobutyl-(3-nitro-benzenesulfonyl)-amino]-propyl-carbamoyl}-2,2-dimethyl-propylcarbamoyl)-methyl]-(3-fluorobenzyl)-carbamic acid tert-butyl ester

2-amino-N-{1-[2H₅]phenylmethyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-3,3-dimethylbutyramide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 856765-77-0 3S-[N-(tert-butyloxycarbonyl)amino-1-(2-methylpropyl)amino-4-[2H₅]phenyl]butan-2R-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send