((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol

Base Information

• Chemical Name: ((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol
• CAS No.: 188347-61-7
• Molecular Formula: C₁₇H₂₄O₂
• Molecular Weight: 260.376
• Mol file: 188347-61-7.mol

Synonyms:((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol

Chemical Property of ((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol

There total 3 articles about ((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(1S,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carboxylic acid methyl ester (188347-60-6) → ((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol (188347-61-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

DOI:10.1016/S0040-4020(96)01077-0

Reference yield:

benzyl bromide (100-39-0) → ((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol (188347-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.6 g / NaH / tetrahydrofuran / 2 h / Ambient temperature

2: 78 percent / LiAlH₄ / diethyl ether / 0 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4020(96)01077-0

Reference yield:

methyl (1S, 2R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptane-1-carboxylate (125637-48-1) → ((1R,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl)-methanol (188347-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.6 g / NaH / tetrahydrofuran / 2 h / Ambient temperature

2: 78 percent / LiAlH₄ / diethyl ether / 0 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4020(96)01077-0

upstream raw materials:

(1S,2R,4R)-2-Benzyloxy-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carboxylic acid methyl ester

benzyl bromide

methyl (1S, 2R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>heptane-1-carboxylate

Downstream raw materials:

(4aR,7aR)-3-Benzyloxy-5-[(1S,2R,4R)-2-(2,2-dimethyl-propoxy)-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carbonyl]-6-oxo-4a,5,6,7a-tetrahydro-oxazolo[5,4-e][1,3,4]oxadiazine-1-carboxylic acid benzyl ester

(4aS,7aS)-3-Benzyloxy-5-[(1S,2R,4R)-2-(2,2-dimethyl-propoxy)-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carbonyl]-6-oxo-4a,5,6,7a-tetrahydro-oxazolo[5,4-e][1,3,4]oxadiazine-1-carboxylic acid benzyl ester

(1R, 2R)-2-benzyloxy-1-methoxymethoxymethyl-7,7-dimethylbicyclo[2.2.1]heptane