ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate

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Chemical Name:ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate
CAS No.:468068-12-4
Molecular Formula:C₂₆H₃₇N₃O₅
Molecular Weight:471.597
Hs Code.:

Synonyms:ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate

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Chemical Property of ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate

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Technology Process of ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate

There total 7 articles about ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 468068-11-3
ethyl 2-[amino(hydroxyimino)methyl]isonicotinate

: 468068-12-4
ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 20 °C

2: 18.9 g / xylene / Heating

With 1,1'-carbonyldiimidazole; In dichloromethane; xylene;
DOI:10.1021/jm061010z

Reference yield:

: 58481-14-4
2-cyano-isonicotinic acid ethyl ester

: 468068-12-4
ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.8 g / hydroxylamine hydrochloride; Et₃N / methanol / 20 °C

2: 1,1-carbonyldiimidazole / CH₂Cl₂ / 20 °C

3: 18.9 g / xylene / Heating

With hydroxylamine hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; In methanol; dichloromethane; xylene;
DOI:10.1021/jm061010z

Reference yield:

: 343251-07-0
(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid

: 468068-12-4
ethyl 2-{5-[(1R)-1-(2-tert-butoxy-2-oxoethyl)-4-cyclohexylbutyl]-1,2,4-oxadiazol-3-yl}isonicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 20 °C

2: 18.9 g / xylene / Heating

With 1,1'-carbonyldiimidazole; In dichloromethane; xylene;
DOI:10.1021/jm061010z