tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate

Base Information

Chemical Name:tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate
CAS No.:468068-15-7
Molecular Formula:C₂₅H₃₆N₄O₄
Molecular Weight:456.585
Hs Code.:

Synonyms:tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate

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Chemical Property of tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate

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Technology Process of tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate

There total 6 articles about tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 468068-11-3
ethyl 2-[amino(hydroxyimino)methyl]isonicotinate

: 468068-15-7
tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 20 °C

2: 18.9 g / xylene / Heating

3: 0.18 g / ethanol; tetrahydrofuran / 96 h / 20 - 45 °C

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dichloromethane; xylene;
DOI:10.1021/jm061010z

Reference yield:

: 58481-14-4
2-cyano-isonicotinic acid ethyl ester

: 468068-15-7
tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 2.8 g / hydroxylamine hydrochloride; Et₃N / methanol / 20 °C

2: 1,1-carbonyldiimidazole / CH₂Cl₂ / 20 °C

3: 18.9 g / xylene / Heating

4: 0.18 g / ethanol; tetrahydrofuran / 96 h / 20 - 45 °C

With hydroxylamine hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; ethanol; dichloromethane; xylene;
DOI:10.1021/jm061010z

Reference yield:

: 343251-07-0
(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid

: 468068-15-7
tert-butyl (3R)-6-cyclohexyl-3-(3-{4-[(methylamino)carbonyl]-2-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 20 °C

2: 18.9 g / xylene / Heating

3: 0.18 g / ethanol; tetrahydrofuran / 96 h / 20 - 45 °C

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dichloromethane; xylene;
DOI:10.1021/jm061010z