{(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

Base Information

Chemical Name:{(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol
CAS No.:1220329-01-0
Molecular Formula:C₂₀H₂₄FNO₃
Molecular Weight:345.414
Hs Code.:

Synonyms:{(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

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Chemical Property of {(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

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Technology Process of {(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

There total 2 articles about {(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220328-99-3
(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2-fluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

: 1220329-01-0
{(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

Guidance literature:: (3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2-fluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole; With acetic acid; zinc; at 20 ℃;

With sodium hydroxide; In water;

Reference yield:

: 1220329-01-0
{(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

Guidance literature:: With acetic acid; zinc; In ethyl acetate; for 18h;

Reference yield:

: 1220329-01-0
{(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

: 532-55-8
Benzoyl isothiocyanate

: 1220329-03-2
(4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine

Guidance literature:: {(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol; Benzoyl isothiocyanate; In dichloromethane; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; for 5h; Reflux;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; for 5h; Reflux;