(4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine

Base Information

Chemical Name:(4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine
CAS No.:1220329-03-2
Molecular Formula:C₂₁H₂₃FN₂O₂S
Molecular Weight:386.49
Hs Code.:

Synonyms:(4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine

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Chemical Property of (4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine

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Technology Process of (4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine

There total 1 articles about (4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220329-01-0
{(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol

: 532-55-8
Benzoyl isothiocyanate

: 1220329-03-2
(4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine

Guidance literature:: {(2R,4R,5S)-5-amino-2-[(benzyloxy)methyl]-5-(2-fluorophenyl)tetrahydro-2H-pyran-4-yl}methanol; Benzoyl isothiocyanate; In dichloromethane; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; for 5h; Reflux;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; for 5h; Reflux;

Reference yield:

: 1220329-03-2
(4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine

: 1220329-04-3
[(4aR,6R,8aS)-2-amino-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl]methanol

Guidance literature:: (4aR,6R,8aS)-6-benzyloxymethyl-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-ylamine; With hydrogenchloride; water; for 2h; Reflux;

With sodium hydroxide; In water; at 20 ℃; Cooling with ice;