tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

Base Information

Chemical Name:tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate
CAS No.:320782-53-4
Molecular Formula:C₅₀H₆₃N₅O₈
Molecular Weight:862.079
Hs Code.:

tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

Synonyms:tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

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Chemical Property of tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

Chemical Property:

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Technology Process of tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

There total 6 articles about tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 320782-52-3
tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-amino(9-fluorenylmethoxycarbonyl)phenylalaninate

: 320782-53-4
tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1021/jm000345s

Reference yield:

: 47375-34-8
Boc-Tyr(t-Bu)-OH

: 320782-53-4
tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / PyBOP; DIPEA / CH₂Cl₂ / 20 °C

2: 30percent H₂O₂; 1 N NaOH / dioxane

3: PyBOP; DIPEA / dimethylformamide

4: piperidine / dimethylformamide / 1.5 h / 20 °C

With piperidine; sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000345s

Reference yield:

: 320782-40-9
tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 320782-53-4
tert-butyl tert-butyloxycarbonyl-O-tert-butyl-L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-phenylalanyl-L-4-aminophenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: PyBOP; DIPEA / dimethylformamide

2: piperidine / dimethylformamide / 1.5 h / 20 °C

With piperidine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm000345s