phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Base Information

Chemical Name:phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
CAS No.:320782-39-6
Molecular Formula:C₃₄H₄₀N₂O₆
Molecular Weight:572.701
Hs Code.:

Synonyms:phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

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Chemical Property of phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

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Technology Process of phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

There total 1 articles about phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 47375-34-8
Boc-Tyr(t-Bu)-OH

: phenyl L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate trifluoroacetate

: 320782-39-6
phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm000345s

Reference yield:

: 320782-39-6
phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 320782-40-9
tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane;
DOI:10.1021/jm000345s

Reference yield:

: 320782-39-6
phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: L-tyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carbonyl-L-4-aminophenylalanyl-L-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: 30percent H₂O₂; 1 N NaOH / dioxane

2: PyBOP; DIPEA / dimethylformamide

3: piperidine / dimethylformamide / 1.5 h / 20 °C

4: 80 percent / TFA; anisole / 1 h / 20 °C

With piperidine; sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm000345s