8-benzylsulfanyl-6-oxo-octanoic acid methyl ester

Base Information

• Chemical Name: 8-benzylsulfanyl-6-oxo-octanoic acid methyl ester
• CAS No.: 101277-59-2
• Molecular Formula: C₁₆H₂₂O₃S
• Molecular Weight: 294.415
• Mol file: 101277-59-2.mol

Synonyms:8-benzylsulfanyl-6-oxo-octanoic acid methyl ester

Chemical Property of 8-benzylsulfanyl-6-oxo-octanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 8-benzylsulfanyl-6-oxo-octanoic acid methyl ester

There total 2 articles about 8-benzylsulfanyl-6-oxo-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-oxooct-7-enoate (41324-23-6) + phenylmethanethiol (100-53-8) → 8-benzylsulfanyl-6-oxo-octanoic acid methyl ester (101277-59-2)

Guidance literature:

With sodium hydride;

DOI:10.1021/ja01565a059

Reference yield:

methyl adipoyl chloride (35444-44-1) → 8-benzylsulfanyl-6-oxo-octanoic acid methyl ester (101277-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium chloride; 1,2-dichloro-ethane / anschliessendes Behandeln mit Wasser und Aethylacetat und Erwaermen der nichtwaessrigen Phase mit Natriumacetat

2: NaH

With aluminium trichloride; sodium hydride; 1,2-dichloro-ethane;

DOI:10.1021/ja01565a059

Reference yield:

8-benzylsulfanyl-6-oxo-octanoic acid methyl ester (101277-59-2) → Thioctic acid (1077-28-7,62-46-4)

Guidance literature:

With cobalt polysulfide; hydrogen; sulfur; acetic acid; at 175 ℃; under 58840.6 - 73550.8 Torr; anschl. mit wss. NaOH und Behandeln der mit Eisen(III)-chlorid versetzten wss. Loesung mit Sauerstoff;

DOI:10.1021/ja01565a059

upstream raw materials:

methyl 6-oxooct-7-enoate

phenylmethanethiol

methyl adipoyl chloride

Downstream raw materials:

Thioctic acid