Technology Process of 4-chloro-2-(2-chloro-6-fluoro-4-iodophenyl)thiazolo[5,4-c]pyridine
There total 12 articles about 4-chloro-2-(2-chloro-6-fluoro-4-iodophenyl)thiazolo[5,4-c]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide;
With
thionyl chloride;
at 90 ℃;
for 120h;
With
pyridine; thiourea;
In
isopropyl alcohol;
at 85 ℃;
for 4h;
With
triethylamine;
In
isopropyl alcohol;
at 85 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 12 h / 100 °C / 20686.5 Torr / Inert atmosphere
2.1: sodium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: pH 3
3.1: triethylamine; diphenyl phosphoryl azide / 20 h / 85 °C
4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
4.2: pH 10
5.1: hydrogenchloride; sodium nitrite / water / 0 °C
5.2: 0 - 20 °C
6.1: pyridine; lithium iodide / 4 h / 115 °C
6.2: pH 4
7.1: thionyl chloride / 2 h / 80 °C
8.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C
8.2: -78 °C
9.1: thionyl chloride / 120 h / 90 °C
9.2: 4 h / 85 °C
9.3: 4 h / 85 °C
With
pyridine; hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium iodide; lithium hexamethyldisilazane; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: pH 3
2.1: triethylamine; diphenyl phosphoryl azide / 20 h / 85 °C
3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
3.2: pH 10
4.1: hydrogenchloride; sodium nitrite / water / 0 °C
4.2: 0 - 20 °C
5.1: pyridine; lithium iodide / 4 h / 115 °C
5.2: pH 4
6.1: thionyl chloride / 2 h / 80 °C
7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C
7.2: -78 °C
8.1: thionyl chloride / 120 h / 90 °C
8.2: 4 h / 85 °C
8.3: 4 h / 85 °C
With
pyridine; hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium iodide; lithium hexamethyldisilazane; sodium nitrite;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
