2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide

Base Information

Chemical Name:2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide
CAS No.:1365993-13-0
Molecular Formula:C₁₂H₅Cl₂F₂IN₂O
Molecular Weight:428.992
Hs Code.:

Synonyms:2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide

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Chemical Property of 2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide

Chemical Property:

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Technology Process of 2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide

There total 10 articles about 2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227577-03-8
2-chloro-3-fluoro-pyridin-4-ylamine

: 1365993-34-5
2-chloro-6-fluoro-4-iodo-benzoyl chloride

: 1365993-13-0
2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide

Guidance literature:: 2-chloro-3-fluoro-pyridin-4-ylamine; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

2-chloro-6-fluoro-4-iodo-benzoyl chloride; In tetrahydrofuran; at -78 ℃;

With ammonium chloride; In water;

Reference yield:

: 1000572-88-2
2,5-dibromo-1-chloro-3-fluorobenzene

: 1365993-13-0
2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 12 h / 100 °C / 20686.5 Torr / Inert atmosphere

2.1: sodium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: pH 3

3.1: triethylamine; diphenyl phosphoryl azide / 20 h / 85 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4.2: pH 10

5.1: hydrogenchloride; sodium nitrite / water / 0 °C

5.2: 0 - 20 °C

6.1: pyridine; lithium iodide / 4 h / 115 °C

6.2: pH 4

7.1: thionyl chloride / 2 h / 80 °C

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

8.2: -78 °C

With pyridine; hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium iodide; lithium hexamethyldisilazane; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1258298-25-7
dimethyl 2-chloro-6-fluoroterephthalate

: 1365993-13-0
2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluoro-4-iodobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: pH 3

2.1: triethylamine; diphenyl phosphoryl azide / 20 h / 85 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.2: pH 10

4.1: hydrogenchloride; sodium nitrite / water / 0 °C

4.2: 0 - 20 °C

5.1: pyridine; lithium iodide / 4 h / 115 °C

5.2: pH 4

6.1: thionyl chloride / 2 h / 80 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

7.2: -78 °C

With pyridine; hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium iodide; lithium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;