ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

Base Information

Chemical Name:ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate
CAS No.:144689-39-4
Molecular Formula:C₂₄H₂₆N₆O₃
Molecular Weight:446.509
Hs Code.:

Synonyms:ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

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Chemical Property of ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

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Technology Process of ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

There total 6 articles about ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 172876-01-6
5-Hydroxymethyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

: 144689-39-4
ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

Guidance literature:: With acetic acid; at 80 ℃; for 2.5h;
DOI:10.1021/jm950450f

Reference yield:

: 144690-54-0
4-hydroxymethyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid ethyl ester

: 144689-39-4
ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

Guidance literature:: In acetic acid; toluene;

Reference yield:

: 58954-23-7
2-propyl-1H-imidazole-4,5-dicarboxylic acid

: 144689-39-4
ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / HCl / Ambient temperature

2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

3: 69 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C

4: 64 percent / 25percent aq. AcOH / 2.5 h / 80 °C

With hydrogenchloride; potassium tert-butylate; diisobutylaluminium hydride; acetic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jm950450f