C₄₅H₆₁BrO₁₁

Base Information

• Chemical Name: C₄₅H₆₁BrO₁₁
• CAS No.: 848854-48-8
• Molecular Formula: C₄₅H₆₁BrO₁₁
• Molecular Weight: 857.877
• Mol file: 848854-48-8.mol

Synonyms:C₄₅H₆₁BrO₁₁

Chemical Property of C₄₅H₆₁BrO₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₆₁BrO₁₁

There total 16 articles about C₄₅H₆₁BrO₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(25R)-3β-(4'-O-benzoyl-2'-bromo-2',6'-dideoxy-α-L-altropyranosyloxy)-5α-spirostan-2-one (848854-44-4) + ethyl chlorocarbonylacetate (36239-09-5) → C45H61BrO11 (848854-48-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.tetasy.2004.11.028

Reference yield:

(25R)-2α-hydroxy-5α-spirostan-3-one (848854-25-1) → C45H61BrO11 (848854-48-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 7.5 g / pyridine / CH₂Cl₂ / 2 h / -40 - 0 °C

2.1: 63 percent / sodium borohydride / methanol; tetrahydrofuran / 0.5 h / 20 °C

3.1: 74 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.58 h / 0 °C

4.1: 73 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾-CHCl₃ adduct; 1,2-bis(diphenylphosphino)ethane / tetrahydrofuran / 6 h / 50 °C

5.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 24 h / 20 °C

6.1: 29 percent / NBS; H₂O; epichlorohydrin / 1,2-dimethoxy-ethane / 2.5 h / 0 - 20 °C

7.1: NaHCO₃

7.2: 70 percent / Bu₂SnO

8.1: 74 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; boron trifluoride diethyl etherate; water; sodium hydrogencarbonate; Dess-Martin periodane; epichlorohydrin; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; 3.1: Ferrier reaction;

DOI:10.1016/j.tetasy.2004.11.028

Reference yield:

(25R)-3-trimethylsilyloxy-5α-spirost-2-ene (881175-98-0) → C45H61BrO11 (848854-48-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: dimethyldioxirane / acetone; CH₂Cl₂ / 0.83 h / 0 °C

2.1: 7.5 g / pyridine / CH₂Cl₂ / 2 h / -40 - 0 °C

3.1: 63 percent / sodium borohydride / methanol; tetrahydrofuran / 0.5 h / 20 °C

4.1: 74 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.58 h / 0 °C

5.1: 73 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾-CHCl₃ adduct; 1,2-bis(diphenylphosphino)ethane / tetrahydrofuran / 6 h / 50 °C

6.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 24 h / 20 °C

7.1: 29 percent / NBS; H₂O; epichlorohydrin / 1,2-dimethoxy-ethane / 2.5 h / 0 - 20 °C

8.1: NaHCO₃

8.2: 70 percent / Bu₂SnO

9.1: 74 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; boron trifluoride diethyl etherate; water; 3,3-dimethyldioxirane; sodium hydrogencarbonate; Dess-Martin periodane; epichlorohydrin; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetone; 4.1: Ferrier reaction;

DOI:10.1016/j.tetasy.2004.11.028

upstream raw materials:

(25R)-3β-(4'-O-benzoyl-2'-bromo-2',6'-dideoxy-α-L-altropyranosyloxy)-5α-spirostan-2-one

ethyl chlorocarbonylacetate

(25R)-2α-hydroxy-5α-spirostan-3-one

(25R)-3-trimethylsilyloxy-5α-spirost-2-ene

Downstream raw materials:

C₄₅H₆₂O₁₂

C₄₅H₆₀O₁₁