N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide

Base Information

Chemical Name:N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide
CAS No.:1542743-98-5
Molecular Formula:C₂₉H₂₃NO₅
Molecular Weight:465.505
Hs Code.:

Synonyms:N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide

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Chemical Property of N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide

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Technology Process of N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide

There total 8 articles about N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 25363-95-5
<(9-oxoxanthen-3-yl)oxy>acetic acid

: 23190-16-1
(1R,2S)-2-Amino-1,2-diphenylethanol

: 1542743-98-5
N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; at 20 ℃; for 5h; enantioselective reaction;
DOI:10.1016/j.bmc.2013.12.042

Reference yield:

: 3722-51-8
3-hydroxyxanthen-9-one

: 1542743-98-5
N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 24 h / Reflux

2: sodium hydroxide / methanol; dichloromethane / 5 h / 20 °C

3: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 5 h / 20 °C

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetone; 1: |Williamson Ether Synthesis;
DOI:10.1016/j.bmc.2013.12.042

Reference yield:

: 21615-34-9
2-Methoxybenzoyl chloride

: 1542743-98-5
N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / diethyl ether / 20 °C

2: sodium hydroxide / methanol; water / 0.5 h / Microwave irradiation

3: aluminum (III) chloride / toluene / Reflux

4: potassium carbonate / acetone / 24 h / Reflux

5: sodium hydroxide / methanol; dichloromethane / 5 h / 20 °C

6: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 5 h / 20 °C

With aluminum (III) chloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; toluene; 4: |Williamson Ether Synthesis;
DOI:10.1016/j.bmc.2013.12.042