3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate

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Chemical Name:3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate
CAS No.:1353642-17-7
Molecular Formula:C₂₇H₃₂N₄O₄
Molecular Weight:476.575
Hs Code.:

Synonyms:3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate

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Chemical Property of 3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate

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Technology Process of 3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate

There total 3 articles about 3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1009080-27-6
N,N-diethyl-2-(2-(4-(3-hydroxypropoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

: 590-93-2
2-Butynoic acid

: 1353642-17-7
3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/mrc.2839

Reference yield:

: 868072-17-7
2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

: 1353642-17-7
3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / dimethyl sulfoxide / 24 h / 50 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With dmap; dicyclohexyl-carbodiimide; sodium hydroxide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/mrc.2839

Reference yield:

: 386297-97-8
2-[2-(4'-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

: 1353642-17-7
3-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)propyl but-2-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / -60 - -20 °C / Inert atmosphere

2: sodium hydroxide / dimethyl sulfoxide / 24 h / 50 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With dmap; boron tribromide; dicyclohexyl-carbodiimide; sodium hydroxide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/mrc.2839