3-ETHOXY-4-METHOXYPHENYLACETONITRILE

Base Information

• Chemical Name: 3-ETHOXY-4-METHOXYPHENYLACETONITRILE
• CAS No.: 103796-99-2
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Hs Code.: 2926909090
• Mol file: 103796-99-2.mol

Synonyms:Acetonitrile,(3-ethoxy-4-methoxyphenyl)- (6CI);3-Ethoxy-4-methoxyphenylacetonitrile;

Chemical Property of 3-ETHOXY-4-METHOXYPHENYLACETONITRILE

Chemical Property:

• Vapor Pressure: 0.000587mmHg at 25°C
• Melting Point: 58-60 °C
• Refractive Index: 1.508
• Boiling Point: 310.8 °C at 760 mmHg
• Flash Point: 117.9 °C
• PSA: 42.25000
• Density: 1.061 g/cm³
• LogP: 2.15998

Purity/Quality:

98%min ^*data from raw suppliers

3-Ethoxy-4-methoxyphenylacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-ETHOXY-4-METHOXYPHENYLACETONITRILE

There total 4 articles about 3-ETHOXY-4-METHOXYPHENYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-ethoxy-4-methoxy-phenyl)-pyruvic acid (876490-82-3) → (3-ethoxy-4-methoxy-phenyl)-acetonitrile (103796-99-2)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; Erhitzen des erhaltenen Oxims mit Acetanhydrid;

DOI:10.1021/ja01275a021

Reference yield:

3-ethoxy-4-methoxybenzaldehyde (1131-52-8) → (3-ethoxy-4-methoxy-phenyl)-acetonitrile (103796-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1: copper oxide-chromium oxide; ethanol / Hydrogenation

2: benzene; hexane; HCl / -10 °C

3: aqueous acetone

With hydrogenchloride; ethanol; hexane; copper oxide-chromium oxide; acetone; benzene;

DOI:10.1021/ja01166a009

Reference yield:

3-ethoxy-4-methoxy-benzyl alcohol (147730-26-5) → (3-ethoxy-4-methoxy-phenyl)-acetonitrile (103796-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene; hexane; HCl / -10 °C

2: aqueous acetone

With hydrogenchloride; hexane; acetone; benzene;

DOI:10.1021/ja01166a009

upstream raw materials:

2-ethoxy-4-chloromethyl-1-methoxy-benzene

potassium cyanide

(3-ethoxy-4-methoxy-phenyl)-pyruvic acid

3-ethoxy-4-methoxybenzaldehyde

Downstream raw materials:

(3-ethoxy-4-methoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide)

(3,4-dimethoxy-phenyl)-acetic acid-(3-ethoxy-4-methoxy-phenethylamide)

6-ethoxy-7-methoxy-1-veratryl-isoquinoline

1-(3-ethoxy-4-methoxy-benzyl)-6,7-dimethoxy-isoquinoline