1131-52-8Relevant articles and documents
Method for synthesizing isovanillin
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Paragraph 0019; 0022-0030; 0040; 0042-0044, (2021/07/31)
The invention provides a method for synthesizing isovanillin, and belongs to the technical field of chemical engineering. The method for synthesizing isovanillin comprises the steps of (1) conducting a methylation reaction, specifically, adding ethyl vanillin, dimethyl sulfoxide, Pd (OAc) 2 and a sodium hydroxide solution into a reaction kettle, carrying out oxygen replacement, controlling the oxygen pressure at 0.2 MPa, reacting at the temperature of 100 DEG C for 6 hours, ending the reaction, and filtering and separating the reaction liquid to obtain an oil-phase intermediate; (2) conducting a hydrolysis reaction, specifically, adding the oil-phase intermediate, a SO4/ZrOTiO2 catalyst and water into the reaction kettle, reacting at the temperature of 65 DEG C, and ending the reaction; carrying out suction filtration on the reaction liquid, dissolving a filter cake with 2000g of ethanol, carrying out heat preservation stirring at the temperature of 60 DEG C for 2-6 hours, and carrying out suction filtration; cooling the filtrate to 0 DEG C, preserving heat and stirring for 2-6 hours, and performing suction filtration to obtain a wet product; and drying the obtained solid in vacuum until the weight is constant to obtain the isovanillin.
AMINO ACID DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
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Page/Page column 47, (2020/08/13)
The present disclosure provides certain amino acid derivatives that inhibit NF-kB activation and are therefore useful for the treatment of inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
New synthesis process for 3-methoxyl-4-ethoxybenzonitrile
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Paragraph 0024; 0028; 0031; 0034, (2017/09/01)
The invention discloses a new synthesis process for 3-methoxyl-4-ethoxybenzonitrile, and relates to the technical field of organic synthesis. The new synthesis process for the 3-methoxyl-4-ethoxybenzonitrile comprises the following steps: taking ethyl vanillin as a raw material, taking N,N-dimethylformamide as a solvent, reacting the raw material and the solvent with potassium carbonate at first to form potassium salt, and reacting the obtained potassium salt with methyl iodide to obtain 3-methoxyl-4-ethoxy-benzaldehyde as an intermediate; adding hydroxylamine hydrochloride in a formic acid solution of the 3-methoxyl-4-ethoxy-benzaldehyde as the intermediate, heating and dehydrating, and carrying out desolventizing and recrystallization to obtain the high-purity 3-methoxyl-4-ethoxybenzonitrile finished product. The ethyl vanillin which is low in cost and is easily obtained as the raw material, aftertreatment operation is simple, and after being recycled, the N,N-dimethylformamide as the solvent can be directly used for other items; the 3-methoxyl-4-ethoxy-benzaldehyde as the intermediate are used for next reaction when not purified, so that purification cost is saved, and yield loss is avoided; and moreover, solid wastes are not produced in the whole process, and the total yield reaches 93.8%.