1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1

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Chemical Name:1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1
CAS No.:1269407-91-1
Molecular Formula:C₂₀H₂₅F₃N₄O₃
Molecular Weight:427.431
Hs Code.:

Synonyms:1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1

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Chemical Property of 1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1

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Technology Process of 1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1

There total 3 articles about 1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1269407-03-5
2-[(3S)-3-amino-1-pyrrolidinyl]-5-(trifluoromethyl)benzonitrile hydrochloride

: 88181-11-7
Boc-L-<2-(2)H>alanine

: 1269407-91-1
1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1269407-02-4
1,1-dimethylethyl {(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}carbamate

: 1269407-91-1
1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane / 1 h / 20 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane;

Reference yield:

: 4088-84-0
2-fluoro-5-trifluoromethyl-benzonitrile

: 1269407-91-1
1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidin-yl}amino)-1-methyl-2-oxoethyl]carbamate-d1

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 100 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;