Technology Process of ER-888363-00
There total 4 articles about ER-888363-00 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C23H18Cl2F3N3O4;
With
lithium hydroxide;
In
1,4-dioxane;
at 60 - 140 ℃;
for 12.3333h;
Microwave irradiation;
With
hydrogenchloride;
In
1,4-dioxane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethyl acetate; diethyl ether
2.1: diisopropyl-carbodiimide; HOBt-6-carboxamidomethyl polystyrene / dmap / dichloromethane; N,N-dimethyl-formamide / 12 h / 40 °C
2.2: 12 h / 40 °C
3.1: lithium hydroxide / 1,4-dioxane / 12.33 h / 60 - 140 °C / Microwave irradiation
With
hydrogenchloride; HOBt-6-carboxamidomethyl polystyrene; lithium hydroxide; diisopropyl-carbodiimide;
dmap;
In
1,4-dioxane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hexane; tetrahydrofuran; methanol / 12 h / 20 °C / Cooling with ice
2.1: hydrogenchloride / ethyl acetate; diethyl ether
3.1: diisopropyl-carbodiimide; HOBt-6-carboxamidomethyl polystyrene / dmap / dichloromethane; N,N-dimethyl-formamide / 12 h / 40 °C
3.2: 12 h / 40 °C
4.1: lithium hydroxide / 1,4-dioxane / 12.33 h / 60 - 140 °C / Microwave irradiation
With
hydrogenchloride; HOBt-6-carboxamidomethyl polystyrene; lithium hydroxide; diisopropyl-carbodiimide;
dmap;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
