6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester

Base Information

Chemical Name:6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester
CAS No.:1224872-05-2
Molecular Formula:C₂₈H₃₀N₄O₃
Molecular Weight:470.571
Hs Code.:

Synonyms:6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester

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Chemical Property of 6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester

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Technology Process of 6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester

There total 4 articles about 6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1224871-89-9
N-indan-5-yl-4-piperazin-1-yl-benzamide

: 49608-01-7
6-chloro-3-pyridinecarboxylic acid ethyl ester

: 1224872-05-2
6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 170 ℃; for 2h; Microwave irradiation;

Reference yield:

: 162046-66-4
4-(4-(1,1-dimethylethoxycarbonyl)piperazin-1-yl)benzoic acid

: 1224872-05-2
6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 170 °C / Microwave irradiation

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 24425-40-9
indan-5-amine

: 1224872-05-2
6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 170 °C / Microwave irradiation

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;