Technology Process of (2R,3R,4S)-4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-ethyl-3-fluoro-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester
There total 12 articles about (2R,3R,4S)-4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-ethyl-3-fluoro-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: KO-tBu / tetrahydrofuran / 3.5 h / 20 °C
2.1: H2 / RaNi / ethyl acetate / 4 h / 20 °C / 3102.97 Torr
2.2: TFA; H2 / 24 h
3.1: DBU / toluene / 12 h / Heating
4.1: CH2Cl2 / 2 h / 20 °C
5.1: aq. NaOH / 2 h / 20 °C
6.1: diethyl ether
7.1: aq. HCl
With
hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene;
RaNi;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
1.1: Henry reaction / 2.1: Michael addition / 8.1: Fischer esterification;
DOI:10.1021/jm010237l
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: TEA / CH2Cl2
2.1: LiCl
3.1: NaH / tetrahydrofuran
4.1: KO-tBu / tetrahydrofuran / 3.5 h / 20 °C
5.1: H2 / RaNi / ethyl acetate / 4 h / 20 °C / 3102.97 Torr
5.2: TFA; H2 / 24 h
6.1: DBU / toluene / 12 h / Heating
7.1: CH2Cl2 / 2 h / 20 °C
8.1: aq. NaOH / 2 h / 20 °C
9.1: diethyl ether
10.1: aq. HCl
With
hydrogenchloride; sodium hydroxide; TEA; potassium tert-butylate; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
RaNi;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
4.1: Michael addition / 10.1: Fischer esterification;
DOI:10.1021/jm010237l
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: KO-tBu / tetrahydrofuran / 3.5 h / 20 °C
2.1: H2 / RaNi / ethyl acetate / 4 h / 20 °C / 3102.97 Torr
2.2: TFA; H2 / 24 h
3.1: DBU / toluene / 12 h / Heating
4.1: CH2Cl2 / 2 h / 20 °C
5.1: aq. NaOH / 2 h / 20 °C
6.1: diethyl ether
7.1: aq. HCl
With
hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene;
RaNi;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
1.1: Michael addition / 7.1: Fischer esterification;
DOI:10.1021/jm010237l
