(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride

Base Information

Chemical Name:(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride
CAS No.:1187450-50-5
Molecular Formula:C₂₃H₂₁N₅O₄S₂*ClH
Molecular Weight:532.044
Hs Code.:

Synonyms:(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride

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Chemical Property of (6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride

Chemical Property:

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Technology Process of (6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride

There total 11 articles about (6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187450-47-0
tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

: 1187450-50-5
(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 14h;

Reference yield:

: 203321-86-2
6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

: 1187450-50-5
(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 1.17 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: ethanol; calcium chloride; sodium tetrahydroborate / Tetraethylene glycol dimethyl ether / 0.92 h / 20 °C / Cooling with ice

2.2: 1.17 h / 20 °C / Cooling with ice

3.1: tributylphosphine; diamide / tetrahydrofuran / 11 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 14 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; tributylphosphine; diamide; sodium hydride; calcium chloride; In tetrahydrofuran; 1,4-dioxane; Tetraethylene glycol dimethyl ether; N,N-dimethyl-formamide; mineral oil; 3.1: Mitsunobu reaction;

Reference yield:

: 1187450-49-2
tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate

: 1187450-50-5
(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tributylphosphine; diamide / tetrahydrofuran / 11 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 14 h / 20 °C

With hydrogenchloride; tributylphosphine; diamide; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction;