tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

Base Information

Chemical Name:tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate
CAS No.:1187450-47-0
Molecular Formula:C₃₂H₃₇N₅O₆S₂
Molecular Weight:651.808
Hs Code.:

Synonyms:tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

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Chemical Property of tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

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Technology Process of tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

There total 9 articles about tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1187450-49-2
tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate

: 1187450-48-1
N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide

: 1187450-47-0
tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

Guidance literature:: With tributylphosphine; diamide; In tetrahydrofuran; at 20 ℃; for 11h;

Reference yield: 85.0%

: 454678-91-2
(4-(thiazol-2-yl)phenyl)methanol

: 1187450-77-6
tert-butyl (tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

: 1187450-47-0
tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

Guidance literature:: With tributylphosphine; diamide; In tetrahydrofuran; at 20 ℃; for 11h;

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1187450-47-0
tert-butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(thiazol-2-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 1.17 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: ethanol; calcium chloride; sodium tetrahydroborate / Tetraethylene glycol dimethyl ether / 0.92 h / 20 °C / Cooling with ice

2.2: 1.17 h / 20 °C / Cooling with ice

3.1: tributylphosphine; diamide / tetrahydrofuran / 11 h / 20 °C

With sodium tetrahydroborate; ethanol; tributylphosphine; diamide; sodium hydride; calcium chloride; In tetrahydrofuran; Tetraethylene glycol dimethyl ether; N,N-dimethyl-formamide; mineral oil; 3.1: Mitsunobu reaction;