6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride

Base Information

Chemical Name:6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride
CAS No.:180208-00-8
Molecular Formula:C₁₇H₁₀Cl₂FN₃O
Molecular Weight:362.19
Hs Code.:

Synonyms:6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride

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Chemical Property of 6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride

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Technology Process of 6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride

There total 11 articles about 6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 75-44-5
phosgene

: 180207-98-1
6-Chloro-3-(4-fluoro-phenyl)-4,5-dihydro-imidazo[1,5-a]quinoxaline

: 180208-00-8
6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; Ambient temperature;
DOI:10.1021/jm960070+

Reference yield:

: 3209-22-1
1,2-Dichloro-3-nitrobenzene

: 180208-00-8
6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride

Guidance literature:: Multi-step reaction with 8 steps

1: EtNiPr₂ / 408 h / 75 °C

2: H₂ / Pt/S/C / ethanol / 16 h / 1551.4 Torr

3: EtNiPr₂ / toluene / 24 h / Heating

4: 1.) KOtBu / 1.) THF, from -20 deg C to 0 deg C, 45 min, 2.) THF, from -40 deg C to RT, 30 min

5: KOtBu / tetrahydrofuran / 3 h / -78 - 20 °C

6: LiAlH₄ / tetrahydrofuran / 96 h / Ambient temperature

7: trifluoroacetic acid, anisole / CH₂Cl₂ / 16 h / Ambient temperature

8: 99 percent / EtNiPr₂ / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; Pt(S)/C; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm960070+

Reference yield:

: 1026844-65-4
(2-Chloro-6-nitro-phenyl)-(3,4-dimethoxy-benzyl)-amine

: 180208-00-8
6-Chloro-3-(4-fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pt/S/C / ethanol / 16 h / 1551.4 Torr

2: EtNiPr₂ / toluene / 24 h / Heating

3: 1.) KOtBu / 1.) THF, from -20 deg C to 0 deg C, 45 min, 2.) THF, from -40 deg C to RT, 30 min

4: KOtBu / tetrahydrofuran / 3 h / -78 - 20 °C

5: LiAlH₄ / tetrahydrofuran / 96 h / Ambient temperature

6: trifluoroacetic acid, anisole / CH₂Cl₂ / 16 h / Ambient temperature

7: 99 percent / EtNiPr₂ / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; Pt(S)/C; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm960070+