N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide

Base Information

Chemical Name:N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide
CAS No.:1302579-13-0
Molecular Formula:C₁₈H₁₈ClN₃O₂
Molecular Weight:343.813
Hs Code.:

Synonyms:N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide

Chemical Property:

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Technology Process of N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide

There total 6 articles about N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 506-68-3
bromocyane

: 1357267-35-6
N-[4-((S)-3-amino-4-hydroxy-butyl)-phenyl]-4-chloro-benzamide

: 1302579-13-0
N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide

Guidance literature:: With sodium acetate; In methanol; at 20 ℃; for 16h;

Reference yield:

: 2609-49-6
diethyl p-nitrobenzylphosphonate

: 1302579-13-0
N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: diisopropylamine; n-butyllithium; aq. hydrochloric acid / hexane; tetrahydrofuran

2: ammonium formate / palladium on charcoal / methanol

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / tetrahydrofuran

4: trifluoroacetic acid / acetonitrile; water

5: sodium acetate / ethyl acetate; n-heptane; methanol

With 4-methyl-morpholine; n-butyllithium; aq. hydrochloric acid; sodium acetate; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine; trifluoroacetic acid; palladium on charcoal; In tetrahydrofuran; methanol; hexane; n-heptane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1302579-22-1
(S)-2,2-dimethyl-4-[(E)-2-(4-nitrophenyl)vinyl]oxazolidine-3-carboxylic acid tert-butyl ester

: 1302579-13-0
N-{4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-4-chloro-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium formate / palladium on charcoal / methanol

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / tetrahydrofuran

3: trifluoroacetic acid / acetonitrile; water

4: sodium acetate / ethyl acetate; n-heptane; methanol

With 4-methyl-morpholine; sodium acetate; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; palladium on charcoal; In tetrahydrofuran; methanol; n-heptane; water; ethyl acetate; acetonitrile;