DIETHYL(4-NITROBENZYL)PHOSPHONATE

Base Information

• Chemical Name: DIETHYL(4-NITROBENZYL)PHOSPHONATE
• CAS No.: 2609-49-6
• Molecular Formula: C11H16NO5P
• Molecular Weight: 273.226
• Hs Code.: 29319090
• Mol file: 2609-49-6.mol

Synonyms:Phosphonicacid, (p-nitrobenzyl)-, diethyl ester (6CI,7CI,8CI);Phosphonic acid,[(4-nitrophenyl)methyl]-, diethyl ester (9CI);(4-Nitrobenzyl)phosphonic aciddiethyl Ester;Diethyl (4-nitrobenzyl)phosphonate;Diethyl(p-nitrobenzyl)phosphonate;NSC 82303;O,O-Diethyl (4-nitrobenzyl)phosphonate;

Chemical Property of DIETHYL(4-NITROBENZYL)PHOSPHONATE

Chemical Property:

• Appearance/Colour: clear slightly viscous yellow-orange to dark red liquid
• Vapor Pressure: 1.55E-06mmHg at 25°C
• Refractive Index: 1.522-1.526
• Boiling Point: 409.3 °C at 760 mmHg
• Flash Point: 201.3 °C
• PSA: 91.16000
• Density: 1.239 g/cm³
• LogP: 3.88410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.0% ^*data from raw suppliers

Diethyl (4-Nitrobenzyl)phosphonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 24/25-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYL(4-NITROBENZYL)PHOSPHONATE

There total 20 articles about DIETHYL(4-NITROBENZYL)PHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromomethyl-4-nitro-benzene (100-11-8) + triethyl phosphite (122-52-1) → diethyl p-nitrobenzylphosphonate (2609-49-6)

Guidance literature:

at 80 ℃; for 4h;

DOI:10.1021/ma0305333

Reference yield: 99.0%

4-nitrobenzylphosphonic acid (1205-62-5) + Triethyl orthoacetate (78-39-7) → diethyl p-nitrobenzylphosphonate (2609-49-6)

Guidance literature:

at 90 ℃; for 24h; Green chemistry;

DOI:10.3390/molecules26185637

Reference yield: 90.0%

4-nitrobenzyl chloride (100-14-1) + triethyl phosphite (122-52-1) → diethyl p-nitrobenzylphosphonate (2609-49-6)

Guidance literature:

In ethanol; at 140 ℃; for 14h;

DOI:10.1080/10426507.2015.1049741

upstream raw materials:

O,O-diethyl benzylphosphonate

sodium diethyl phosphite

4-nitrobenzyl chloride

diethyl phosphite potassium salt

Downstream raw materials:

tert-butyl N-[(2E)-3-(4-nitrophenyl)prop-2-en-1-yl]carbamate

2-<4-<(trifluoroacetyl)amino>phenyl>-1-(4-nitrophenyl)-(E)-prop-1-ene

(E)-4-methyl-4'-nitrostilbene

[(Z)-2-Dimethylamino-1-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester

Refernces

• 1、 Kuo, Wen-Jang,Hsiue, Ging-Ho,Jeng, Ru-Jong. "Synthesis and macroscopic second-order nonlinear optical properties of poly(ether imide)s containing a novel two-dimensional carbazole chromophore with nitro acceptors". . p. 868 - 878. Retrieved 2002.
• 2、 Hosseini-Sarvari, Mona,Koohgard, Mehdi. "Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine". . p. 5905 - 5911. Retrieved 2021/07/12.
• 3、 -. "Novel compounds useful as fluorescent probes selectively binding to tau aggregates and preparation method thereof". Paragraph 0365-0368. . Retrieved 2021/01/29.