3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

Base Information

Chemical Name:3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene
CAS No.:351379-12-9
Molecular Formula:C₂₄H₂₅IO₄
Molecular Weight:504.365
Hs Code.:

Synonyms:3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

Suppliers and Price of 3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

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Chemical Property of 3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

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Technology Process of 3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

There total 5 articles about 3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351379-10-7
2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol

: 351379-12-9
3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

2.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

2.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja050203t

Reference yield:

: 351378-60-4
2-hydroxy-5-iodo-3-methylphenyl 4-methylbenzenesulfonate

: 351379-12-9
3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / K₂CO₃ / acetone / 12 h / Heating

2.1: 90 percent / aq. NaOH / ethane-1,2-diol / 5 h / Heating

3.1: Et₂AlCl / CH₂Cl₂ / 1 h / 20 °C

3.2: 86 percent / CH₂Cl₂ / 24 h / 20 °C

4.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

5.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

5.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

With sodium hydroxide; diethylaluminium chloride; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja050203t

Reference yield:

: 488-17-5
3-methylbenzene-1,2-diol

: 351379-12-9
3-Benzyloxy-1-iodo-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 84 percent / TEA / CH₂Cl₂ / 12 h / 20 °C

2.1: 96 percent / ICl; AcOH / 12 h / 70 °C

3.1: 95 percent / K₂CO₃ / acetone / 12 h / Heating

4.1: 90 percent / aq. NaOH / ethane-1,2-diol / 5 h / Heating

5.1: Et₂AlCl / CH₂Cl₂ / 1 h / 20 °C

5.2: 86 percent / CH₂Cl₂ / 24 h / 20 °C

6.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

7.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

7.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

With sodium hydroxide; TEA; diethylaluminium chloride; Iodine monochloride; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja050203t