N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide

Base Information

Chemical Name:N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide
CAS No.:1602830-77-2
Molecular Formula:C₁₆H₂₀ClNO₄S
Molecular Weight:357.858
Hs Code.:

Synonyms:N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide

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Chemical Property of N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide

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Technology Process of N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide

There total 4 articles about N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1602830-74-9
N-((2-methyl-1,3-dioxolan-2-yl)methyl)p-toluenesulfonamide

: 821-10-3
1,4-Dichloro-2-butyne

: 1602830-77-2
N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide

Guidance literature:: N-((2-methyl-1,3-dioxolan-2-yl)methyl)p-toluenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

With 15-crown-5; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h; Inert atmosphere;

1,4-Dichloro-2-butyne; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201304033

Reference yield:

: 1,1-dimethylethyl N-[[4-methylphenyl]sulfonyl]-N-(2-oxopropyl)carbamate

: 1602830-77-2
N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / benzene / 24 h / Dean-Stark; Reflux; Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

3.3: 12 h / 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1002/chem.201304033

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 1602830-77-2
N-(4-chlorobut-2-yn-1-yl)-N-((2-methyl-1,3-dioxolan-2 yl)methyl)p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 20 °C / Inert atmosphere

1.3: 12 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / benzene / 24 h / Dean-Stark; Reflux; Inert atmosphere

4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

4.2: 0.25 h / 20 °C / Inert atmosphere

4.3: 12 h / 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1002/chem.201304033