2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid

Base Information

Chemical Name:2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid
CAS No.:258351-79-0
Molecular Formula:C₂₅H₃₅NO₄Si
Molecular Weight:441.643
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-4-(<i>tert</i>-butyl-diphenyl-silanyl)-butyric acid

Synonyms:2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid

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Chemical Property of 2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid

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Technology Process of 2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid

There total 4 articles about 2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 258351-77-8
N-[(1R)-1-(4,4-dimethyl-3,3-diphenyl-3-silapentyl)-2-hydroxyethyl](tert-butoxy)carboxamide

: 258351-79-0
2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid

Guidance literature:: With periodic acid; chromium(VI) oxide; In water; acetonitrile; for 0.5h;
DOI:10.1021/jo991272r

Reference yield:

: 162107-48-4
tert-butyl (R)-4-ethynyl-2,2-dimethyloxazolidine-3-carboxylate

: 258351-79-0
2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / tetrahydrofuran / 2 h / -78 °C

2: 88 percent / H₂ / Pd on carbon / aq. ethanol; petroleum ether / 7 h / 760 Torr

3: 96 percent / CF₃COOH / methanol / 5 h / 0 °C

4: 70 percent / H₅IO₆ / CrO₃ / acetonitrile; H₂O / 0.5 h

With hydrogen; periodic acid; trifluoroacetic acid; chromium(VI) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; acetonitrile; Petroleum ether; 1: Addition / 2: Catalytic hydrogenation / 3: Ring cleavage / 4: Oxidation;
DOI:10.1021/jo991272r

Reference yield:

: 258351-75-6
tert-butyl (4R)-4-((1E)-4,4-dimethyl-3,3-diphenyl-3-silapent-1-enyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 258351-79-0
2-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyl)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / H₂ / Pd on carbon / aq. ethanol; petroleum ether / 7 h / 760 Torr

2: 96 percent / CF₃COOH / methanol / 5 h / 0 °C

3: 70 percent / H₅IO₆ / CrO₃ / acetonitrile; H₂O / 0.5 h

With hydrogen; periodic acid; trifluoroacetic acid; chromium(VI) oxide; palladium on activated charcoal; In methanol; ethanol; water; acetonitrile; Petroleum ether; 1: Catalytic hydrogenation / 2: Ring cleavage / 3: Oxidation;
DOI:10.1021/jo991272r