[(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Base Information

Chemical Name:[(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol
CAS No.:1425947-54-1
Molecular Formula:C₁₂H₁₅F₂NO₂
Molecular Weight:243.253
Hs Code.:

Synonyms:[(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

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Technology Process of [(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

There total 7 articles about [(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1425947-53-0
(3aR,7aS)-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

: 1425947-54-1
[(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Guidance literature:: With acetic acid; zinc; In ethyl acetate; for 18h;

Reference yield:

: 1425947-52-9
(3aR)-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole

: 1425947-54-1
[(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: acetic acid; zinc / ethyl acetate / 18 h

With n-butyllithium; acetic acid; zinc; In tetrahydrofuran; hexane; ethyl acetate; toluene;

Reference yield:

: 1220327-09-2
3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole

: 1425947-54-1
[(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Chiralpak AS-H / isopropyl alcohol; carbon dioxide / Resolution of racemate; liquid CO₂

2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1 h / -78 °C

2.2: 1 h / -78 °C

3.1: acetic acid; zinc / ethyl acetate / 18 h

With n-butyllithium; acetic acid; zinc; In tetrahydrofuran; hexane; carbon dioxide; ethyl acetate; isopropyl alcohol; toluene;