9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate
CAS No.:1425947-55-2
Molecular Formula:C₂₈H₂₆F₂N₂O₄S
Molecular Weight:524.588
Hs Code.:

Synonyms:9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate

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Chemical Property of 9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate

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Technology Process of 9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate

There total 8 articles about 9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1425947-54-1
[(3S,4R)-3-amino-3-(2,4-difluorophenyl)tetrahydro-2H-pyran-4-yl]methanol

: 199915-38-3
9-fluorenylmethoxycarbonyl isothiocyanate

: 1425947-55-2
9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1425947-52-9
(3aR)-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole

: 1425947-55-2
9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: acetic acid; zinc / ethyl acetate / 18 h

3.1: dichloromethane / 4 h / 20 °C

With n-butyllithium; acetic acid; zinc; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1425947-53-0
(3aR,7aS)-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

: 1425947-55-2
9H-fluoren-9-ylmethyl [(3S,4R)-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; zinc / ethyl acetate / 18 h

2: dichloromethane / 4 h / 20 °C

With acetic acid; zinc; In dichloromethane; ethyl acetate;