Trt-Gly-Phe-Gly-Gly-OBn

Base Information

• Chemical Name: Trt-Gly-Phe-Gly-Gly-OBn
• CAS No.: 173723-57-4
• Molecular Formula: C₄₁H₄₀N₄O₅
• Molecular Weight: 668.792
• Mol file: 173723-57-4.mol

Synonyms:Trt-Gly-Phe-Gly-Gly-OBn

Chemical Property of Trt-Gly-Phe-Gly-Gly-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Trt-Gly-Phe-Gly-Gly-OBn

There total 2 articles about Trt-Gly-Phe-Gly-Gly-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Gly-Phe-OH (3321-03-7) → Trt-Gly-Phe-Gly-Gly-OBn (173723-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / diethylamine / H₂O; propan-2-ol / 1 h

2: 1.) HOSu, DCC, 2.) N-methylmorpholine / 1.) DMF, 4 deg C, 2 h, 2.) DMF, 4 deg C, 15 h

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; diethylamine; dicyclohexyl-carbodiimide; In water; isopropyl alcohol;

DOI:10.1248/cpb.43.1931

Reference yield:

N-tritylglycyl-L-phenylalanine (76378-71-7) + glycylglycine benzyl ester p-toluene sulfonate salt (1738-82-5) → Trt-Gly-Phe-Gly-Gly-OBn (173723-57-4)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, 4 deg C, 2 h, 2.) DMF, 4 deg C, 15 h;

DOI:10.1248/cpb.43.1931

Reference yield: 95.0%

Trt-Gly-Phe-Gly-Gly-OBn (173723-57-4) → Trt-Gly-Phe-Gly-Gly-OH (161254-11-1)

Guidance literature:

With cyclohexa-1,4-diene; palladium on activated charcoal; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.43.1931

upstream raw materials:

N-tritylglycyl-L-phenylalanine

glycylglycine benzyl ester p-toluene sulfonate salt

Gly-Phe-OH

Downstream raw materials:

Trt-Gly-Phe-Gly-Gly-OH

C₆₁H₆₁N₅O₁₅

Refernces