76378-71-7

Upstream product

• 5893-05-0 Trt-Gly 
• 541-41-3 chloroformic acid ethyl ester 
• 121-44-8 triethylamine 
• 3321-03-7 Gly-Phe-OH 
• 76-83-5 trityl chloride 
• 131326-15-3 L-phenylalanine 4-chlorobutyl ester hydrochloride 
• 88962-26-9 L-phenylalanine 2-bromoethyl ester hydrochloride 
• 63-91-2 L-phenylalanine 
• 131326-22-2 N-tritylglycyl-L-phenylalanine 4-chlorobutyl ester 
• 123873-00-7 N-tritylglycyl-L-phenylalanine 2-bromoethyl ester 

Downstream Products

• 1053255-25-6 C₆₁H₆₁N₅O₁₅ 
• 161254-11-1 Trt-Gly-Phe-Gly-Gly-OH 
• 173723-57-4 Trt-Gly-Phe-Gly-Gly-OBn 
• 103331-61-9 N-trityl-glycyl=>phenylalanyl=>glycine ethyl ester; N-trityl-glycyl=>L-phenylalanyl=>glycine ethyl ester 
• 3321-03-7 Gly-Phe-OH 

Relevant academic research and scientific papers

Synthesis of carboxymethylpullulan-peptide-doxorubicin conjugates and their properties

The amino group of doxorubicin (DXR) was found to be bound to the carboxyl group of carboxymethylpullulan (CMPul) either directly or through tetrapeptide spacers, including Gly-Gly-Phe-Gly, Gly-Phe-Gly-Gly and Gly- Gly-Gly-Gly. These conjugates had DXR co

USE OF 4-CHLOROBUTYL ESTERS IN PEPTIDE SYNTHESIS

Ho and Wong synthesised 4-chlorobutyl esters of simple carboxylic acids and removed the ester group by the action of sodium sulfide under reflux conditions.We describe here the synthesis of the 4-chlorobutyl esters of glycine and L-phenylalanine and its use in the synthesis of six new N-protected dipeptides 4-chlorobutyl esters (XHNCH2CO-HNCHRCO2(CH2)4Cl; R = H, CH2Ph; X = Z, Boc, Trt).The selective removal of the 4-chlorobutyl group can be achieved by the action of the sulfide anion in aqueous acetonitrile (room temperature, 1.5 to 5 h).The conditions are milder than those described, but similar to the conditions used with the dipeptides 2-bromoethyl esters.The N-protected dipeptides were isolated in 50 to 80percent yield.

NEW APPROACH TO THE USE OF 2-BROMOETHYL ESTERS IN PEPTIDE SYNTHESIS

The synthesis of six fully protected dipeptides 2-bromoethyl esters and a new method for the removal of the C-protection by the action of the sulphide anion, at room temperature, are described.