1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate
CAS No.:1047645-46-4
Molecular Formula:C₁₉H₂₂BrClN₂O₃S
Molecular Weight:473.818
Hs Code.:

Synonyms:1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

There total 5 articles about 1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 60729-37-5
4-bromo-5-chlorothiophene-2-carboxylic acid

: 162541-45-9
(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol

: 1047645-46-4
1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

Guidance literature:: 4-bromo-5-chlorothiophene-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 25 ℃; for 0.5h;

(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol; In dichloromethane; for 2h;

Reference yield:

: 50411-26-2
3-phenyl-2-hydroxypropylamine

: 1047645-46-4
1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 0.5 h / 25 °C

2.2: 2 h

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 1047645-46-4
1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: iron(III) chloride; bromine / acetic acid / 168 h / 25 °C / Heating / reflux

2.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 0.5 h / 25 °C

2.2: 2 h

With iron(III) chloride; bromine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; acetic acid;