N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide
CAS No.:623549-61-1
Molecular Formula:C₁₀H₁₀F₆N₂O₂
Molecular Weight:304.192
Hs Code.:

Synonyms:N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide

There total 5 articles about N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 354-32-5
trifluoracetyl chloride

: 129884-37-3,782445-78-7,1241684-26-3,208533-40-8
cis-4,5-diaminocyclohexene

: 623549-61-1
N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide

Guidance literature:: With triethylamine; In dichloromethane; at -78 - 20 ℃; for 16h;
DOI:10.1039/b303081d

Reference yield:

: 1165952-92-0
cyclohexa-1,4-diene

: 623549-61-1
N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / N-methylmorpholine N-oxide; aq. OsO₄ / acetone / 4 h

2: 4.94 g / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

3: 321 mg / NaN₃ / dimethylsulfoxide / 48 h / 80 °C

4: 825 mg / LiAlH₄ / diethyl ether / 1 h / 0 °C

5: 65 percent / Et₃N / CH₂Cl₂ / 16 h / -78 - 20 °C

With osmium(VIII) oxide; lithium aluminium tetrahydride; sodium azide; 4-methylmorpholine N-oxide; triethylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide; acetone; 1: UpJohn oxidation;
DOI:10.1039/b303081d

Reference yield:

: 406682-04-0
cis-cyclohex-4-ene-1,2-diol

: 623549-61-1
N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4.94 g / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

2: 321 mg / NaN₃ / dimethylsulfoxide / 48 h / 80 °C

3: 825 mg / LiAlH₄ / diethyl ether / 1 h / 0 °C

4: 65 percent / Et₃N / CH₂Cl₂ / 16 h / -78 - 20 °C

With lithium aluminium tetrahydride; sodium azide; triethylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/b303081d