354-32-5

Basic information

• Product Name: TRIFLUOROACETYL CHLORIDE
• Synonyms: TRIFLUOROACETYL CHLORIDE;Acetyl chloride, trifluoro-;perfluoroacetylchloride;trifluoro-acetylchlorid;TRIFLUOROACETYL CHLORIDE CYL. WITH 800;Trifluoroacetylchloride97%;Trifluoracetylchlorid;Trifluoroacetic acid chloride
• CAS NO: 354-32-5
• Molecular Formula: C₂ClF₃O
• Molecular Weight: 132.47
• EINECS: 206-556-2
• Product Categories: Chemical Synthesis;Compressed and Liquefied Gases;Synthetic Reagents;Chemical Synthesis;Specialty Gases;Synthetic Reagents
• Mol File: 354-32-5.mol
• Article Data: 35

Chemical Properties

• Melting Point: −146 °C(lit.)
• Boiling Point: −27 °C(lit.)
• Flash Point: -58.1±25.9℃
• Appearance: /
• Density: 1,335 g/cm3
• Vapor Density: 4.6 (vs air)
• Vapor Pressure: 3760mmHg at 25°C
• Refractive Index: 1.309
• BRN: 1098994
• CAS DataBase Reference: TRIFLUOROACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIFLUOROACETYL CHLORIDE(354-32-5)
• EPA Substance Registry System: TRIFLUOROACETYL CHLORIDE(354-32-5)

Safety Data

• Hazard Codes: C
• Statements: 14-35-37
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3057 2.3
• WGK Germany: 2
• RTECS: AO7150000
• F: 4.5-19-21
• HazardClass: 2.3
• Hazardous Substances Data: 354-32-5(Hazardous Substances Data)

Usage

Uses

Widely used in medicine, pesticides, organic intermediate and fine chemical.

General Description

A colorless gas. Shipped as a liquid under own vapor pressure. Contact with the unconfined liquid may frostbite unprotected skin. Very toxic by inhalation and may severely irritate skin, eyes, and mucous membranes. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.

Air & Water Reactions

Reacts avidly with water and with moisture in the air to give fumes of hydrogen chloride, a water-soluble toxic gas.

Reactivity Profile

TRIFLUOROACETYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines, alkalis. Reacts vigorously with amines and alkalis. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.

Fire Hazard

Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

Flammability and Explosibility

Notclassified

Safety Profile

Corrosive to skin, eyes, and materials. When heated to decomposition it emits very toxic fumes of Fand Cl-. See also FLUORIDES and CHLORIDES.

Synthetic route

2,2,2-Trifluoroacetaldehyde (75-90-1) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
	100%

trifluoroacetic anhydride (407-25-0) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With 1-methyl-1H-imidazole; diethyl chlorophosphate	94%
With pyridine hydrochloride; trifluoroacetic acid

chloro-trimethyl-silane (75-77-4) + C6H9F3O4S (72500-13-1) → trifluoracetyl chloride (354-32-5) + Trimethylsilyl-1-butansulfonat (72500-12-0)

Conditions	Yield
for 24h; Ambient temperature;	A n/a B 91%

1-Chlor-1,2,2,2-tetrafluorethansulfenylchlorid (57160-01-7) → trifluoracetyl chloride (354-32-5) + trifluorothioacetyl fluoride (754-13-2)

Conditions	Yield
With Cu-cuttings In gas at 400℃; under 0.008 Torr;	A 1% B 89%

trifluorormethanesulfonic acid (1493-13-6) + hexaiodobenzene (608-74-2) → trifluoracetyl chloride (354-32-5) + C6I6(2+)*2CF3O3S(1-) (115162-16-8) + C6ClI5(1+)*2CF3O3S(1-) (115162-13-5)

Conditions	Yield
With chlorine; trifluoroacetyl triflate at 25℃; for 4h; Product distribution; Mechanism; various oxidating agent;	A n/a B 88% C 7%
With chlorine; trifluoroacetyl triflate at 25℃; for 4h;	A n/a B 88% C 7%
With chlorin; trifluoroacetyl triflate at 25℃; for 4h;	A n/a B 88% C 7%

methanesulphonyltrifluoroacetic anhydride (93370-09-3) + acetyl chloride (75-36-5) → trifluoracetyl chloride (354-32-5) + Acetyl methanesulfonate (5539-53-7)

Conditions	Yield
at 50℃; for 1h; Yield given;	A n/a B 86.5%
at 50℃; for 1h; Yields of byproduct given;	A n/a B 86.5%

trifluoroacetic acid (76-05-1) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With phosphorus pentachloride In 1,2-dichloro-ethane for 3h;	81%
With benzoyl chloride at 200℃; for 3.5h;	50%
With phosphorus pentachloride

trifluorothioacetic acid (2925-25-9) → trifluoracetyl chloride (354-32-5) + N-Chlorosulfuryltrifluoroacetimide (132654-09-2)

Conditions	Yield
With isocyanate de chlorosulfonyle Ambient temperature;	A n/a B 66%

1,2-bis(trifluoroacetyl)hydrazine (667-35-6) → trifluoracetyl chloride (354-32-5) + 2,5-dichloro-1,1,1,6,6,6-hexafluoro-3,4-diaza-hexa-2,4-diene (58911-32-3)

Conditions	Yield
With N,N-dimethylaniline hydrochloride; trichlorophosphate Heating; Yield given;	A n/a B 48%
With N,N-dimethylaniline hydrochloride; trichlorophosphate Heating; Yields of byproduct given;	A n/a B 48%

1,1,1-trifluoro-2,2-dichloroethane (306-83-2) → trifluoracetyl chloride (354-32-5) + trifluoroacetic acid (76-05-1)

Conditions	Yield
With oxygen; chlorine Irradiation.UV-Licht;

benzoyl chloride (98-88-4) + trifluoroacetic acid (76-05-1) → trifluoracetyl chloride (354-32-5)

Benzotrichlorid (98-07-7) + trifluoroacetic acid (76-05-1) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With zinc(II) chloride

1,1,1-Trichloro-2,2,2-trifluoroethane (354-58-5) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With sulfur trioxide

sodium 2,2,2-trifluoroacetate (2923-18-4) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With p-toluenesulfonyl chloride

diethyl chlorophosphate (814-49-3) + trifluoroacetic anhydride (407-25-0) → trifluoracetyl chloride (354-32-5) + O,O-Diethyl O-Trifluoroacetyl Phosphate (650-09-9)

Conditions	Yield
With 1-methyl-1H-imidazole Ambient temperature;

trifluoroacetic anhydride (407-25-0) → trifluoracetyl chloride (354-32-5) + O,O-Diethyl O-Trifluoroacetyl Phosphate (650-09-9)

Conditions	Yield
With 1-methyl-1H-imidazole; diethyl chlorophosphate Ambient temperature; Yield given;

1,1,1-trifluoro-2-chloroethylperoxyl radical (88099-83-6) → trifluoracetyl chloride (354-32-5) + 1-Chloro-2,2,2-trifluoro-ethanol + C2HClF3O (147703-34-2)

Conditions	Yield
at 22.9℃; Rate constant; self-reaction;

C2HClF3O (147703-34-2) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With oxygen at 22.9℃; under 700 Torr; Product distribution;

1,1,1-trifluoro-2,2-dichloroethane (306-83-2) → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With oxygen; chlorine Oxidation; Photolysis;	102 %
Stage #1: 1,1,1-trifluoro-2,2-dichloroethane With oxygen at 20 - 40℃; under 1000 - 2000 Torr; Stage #2: for 8h; Conversion of starting material; UV-irradiation;
With ozone; copper(II) sulfate at 30℃; for 730.5h; Reagent/catalyst; Temperature; Irradiation;
With oxygen at 5℃; for 1h; Concentration; Temperature; Irradiation;

trifluoroacetate_of barium → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With phosphorus trichloride

trifluoroacetate_of sodium → trifluoracetyl chloride (354-32-5)

Conditions	Yield
With trichlorophosphate

2,2,2-Trifluoroacetaldehyde (75-90-1) + chlorine (7782-50-5) → trifluoracetyl chloride (354-32-5) + trifluoromethan (75-46-7) + chlorotrifluoromethane (75-72-9)

Conditions	Yield
im UV-Licht;

1,1,1-Trichloro-2,2,2-trifluoroethane (354-58-5) + oxygen → trifluoracetyl chloride (354-32-5) + methylammonium carbonate (15719-64-9, 15719-76-3, 97762-63-5)

Conditions	Yield
UV-Licht.Irradiation;

1,1,1-trifluoro-2,2-dichloroethane (306-83-2) + oxygen → hydrogenchloride (7647-01-0) + trifluoracetyl chloride (354-32-5) + methylammonium carbonate (15719-64-9, 15719-76-3, 97762-63-5) + trifluoroacetic acid (76-05-1)

Conditions	Yield
im UV-Licht;

1,1,1-trifluoro-2,2-dichloroethane (306-83-2) + chlorine (7782-50-5) + oxygen → hydrogenchloride (7647-01-0) + trifluoracetyl chloride (354-32-5) + methylammonium carbonate (15719-64-9, 15719-76-3, 97762-63-5) + trifluoroacetic acid (76-05-1)

Conditions	Yield
im UV-Licht;

3-chlorotrifluoro-1,2-oxathietane 2,2-dioxide (1004-47-3) + 4-chlorotrifluoro-1,2-oxathietane 2,2-dioxide (933-29-9) → chlorotrifluoroethylene oxide (3935-49-7) + trifluoracetyl chloride (354-32-5) + chlorodifluoroacetyl fluoride (354-27-8)

Conditions	Yield
byproducts: SO2; at 245-255°C; detected by IR- and mass spectroscopy;
byproducts: SO2; at 245-255°C;

trans-1-chloro-3,3,3-trifluoropropene (102687-65-0) → trifluoracetyl chloride (354-32-5) + formyl chloride (2565-30-2) + 2,2,2-Trifluoroacetaldehyde (75-90-1) + 3,3,3-trifluoro-2-chloropropionaldehyde (19256-25-8) + 3,3,3-trifluoro-2-chloropropionyl chloride (431-54-9)

Conditions	Yield
With nitrogen; oxygen; chlorine at 21.84℃; under 700 Torr; UV-irradiation;

trans-1-chloro-3,3,3-trifluoropropene (102687-65-0) → trifluoracetyl chloride (354-32-5) + formyl chloride (2565-30-2) + 2,2,2-Trifluoroacetaldehyde (75-90-1) + 3,3,3-trifluoro-2-chloropropionaldehyde (19256-25-8) + 3,3,3-trifluoro-2-chloropropionyl chloride (431-54-9) + 3,3-dichloro-1,1,1-trifluoroacetone (126266-75-9)

Conditions	Yield
With nitrogen; oxygen; chlorine at 21.84℃; under 700 Torr; UV-irradiation;

trans-1-chloro-3,3,3-trifluoropropene (102687-65-0) → trifluoracetyl chloride (354-32-5) + formyl chloride (2565-30-2) + 3,3,3-trifluoro-2-chloropropionaldehyde (19256-25-8) + 3,3,3-trifluoro-2-chloropropionyl chloride (431-54-9) + 3,3-dichloro-1,1,1-trifluoroacetone (126266-75-9)

Conditions	Yield
With nitrogen; oxygen; chlorine at 21.84℃; under 700 Torr; UV-irradiation;

trifluoracetyl chloride (354-32-5) + 2-Amino-3-trifluoromethylsulfanyl-benzoic acid (114351-53-0) → 2-Trifluoromethyl-8-trifluoromethylsulfanyl-benzo[d][1,3]oxazin-4-one (114351-18-7)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane for 20h; Ambient temperature;	100%

trifluoracetyl chloride (354-32-5) + di-H-trifluoroethane-2-sulfonyl fluoride (503-39-9) + triethylamine (121-44-8) → (Z)-1,1,1,4,4,4-Hexafluoro-3-hydroxy-but-2-ene-2-sulfonyl fluoride; compound with triethyl-amine

Conditions	Yield
In diethyl ether at -70 - 20℃;	100%

trifluoracetyl chloride (354-32-5) + ethyl vinyl ether (109-92-2) → 4-chloro-4-ethoxy-1,1,1-trifluoro-3-butan-2-one (1095142-49-6)

Conditions	Yield
at -30℃; Product distribution / selectivity;	100%
at 0 - 25℃; for 3.95h; Product distribution / selectivity;	93%
at 0 - 25℃; for 3.95h; Product distribution / selectivity;	93%

trifluoracetyl chloride (354-32-5) + ethyl vinyl ether (109-92-2) → 4-ethoxy-1,1,1-trifluoro-3-butene-2-one (59938-06-6, 17129-06-5) + 4-chloro-4-ethoxy-1,1,1-trifluoro-3-butan-2-one (1095142-49-6)

Conditions	Yield
With sodium hydroxide at -10 - 80℃; under 262.526 - 760.051 Torr; Product distribution / selectivity;	A 85% B 100%

trifluoracetyl chloride (354-32-5) + 4-dimethylamino-3-buten-2-one (1190-91-6) → 3-dimethylaminomethylene-1,1,1-trifluoro-2,4-pentanedione

Conditions	Yield
In dichloromethane at 0℃; for 2h; Inert atmosphere;	100%

trifluoracetyl chloride (354-32-5) + 3-methyl-5-aminopyrazole (31230-17-8) → 3-trifluoroacetylamino-5-methylpyrazole (198213-31-9)

Conditions	Yield
With triethylamine In 1,4-dioxane at 10 - 20℃;	99%

trifluoracetyl chloride (354-32-5) + 3-dimethylaminoacrylonitrile (2407-68-3) → 2-((dimethylamino)methylene)-4,4,4-trifluoro-3-oxobutyronitrile (339011-85-7)

Conditions	Yield
With pyridine In toluene Product distribution / selectivity; Cooling with ice; Inert atmosphere;	99%

trifluoracetyl chloride (354-32-5) + 2-(2,4-dimethylphenylsulphanyl)benzeneamine (1019453-85-0) → N-(2-(2,4-dimethylphenylthio)phenyl)-2,2,2-trifluoroacetamide

Conditions	Yield
With sodium hydroxide In acetonitrile	98%

trifluoracetyl chloride (354-32-5) + ethanol (64-17-5) → ethyl trifluoroacetate, (383-63-1)

Conditions	Yield
at 35 - 58℃; for 1h; Temperature;	97.86%
With hydrogenchloride In water; ethyl acetate at 40 - 60℃; for 0.333333h; Temperature;

trifluoracetyl chloride (354-32-5) + 2-chloro-2,2-difluoroethanol (464-00-6) → 2-chloro-2,2-difluoroethyl trifluoroacetate

Conditions	Yield
In N,N-dimethyl-formamide for 4h; Heating;	97%

trifluoracetyl chloride (354-32-5) + 2-(2-bromopyridin-3-yl) ethanamine → N-(2-(2-bromopyridin-3-yl)ethyl)-2,2,2-trifluoroacetamide (1310552-76-1)

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	97%

trifluoracetyl chloride (354-32-5) + Hg(NSOF2)2 → sulfinyl difluoride trifluoroacetylimide (56697-78-0)

Conditions	Yield
20°C, 12 h, shaking in autoclave;	96.5%
20°C, 12 h, shaking in autoclave;	96.5%

trifluoracetyl chloride (354-32-5) + 1,1,1-trifluoro-3-(triphenylphosphoranylidene)-2-propanone (55759-55-2) → Bismethylenetriphenylphosphorane

Conditions	Yield
In toluene 1.) 110 deg C, 4 h, 2.) r.t., 1 h;	96%

trifluoracetyl chloride (354-32-5) + 4-((3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7-(8H)-yl)methyl)benzenamine → 2,2,2-trifluoro-N-(4-((3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)acetamide

Conditions	Yield
In acetonitrile at 55℃; for 0.416667h; Microwave irradiation;	96%

trifluoracetyl chloride (354-32-5) + 2-ethoxyprop-1-ene (926-66-9) → 1,1,1-trifluoro-4-ethoxypent-3-en-2-one (144219-75-0)

Conditions	Yield
With diethylamine In cyclohexane at 5 - 10℃; for 3h; Reagent/catalyst; Solvent; Temperature; Large scale;	96%

trifluoracetyl chloride (354-32-5) + 9,10,11-Trimethoxy-3-methylsulfanyl-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-ol (209466-99-9, 209810-40-2, 209810-47-9, 209810-48-0) → Trifluoro-acetic acid 9,10,11-trimethoxy-3-methylsulfanyl-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl ester

Conditions	Yield
In pyridine	95.2%

trifluoracetyl chloride (354-32-5) + 2-Oxa-3-azabicyclo<2.2.2>oct-5-ene hydrochloride (56239-25-9) → N-(trifluoroacetyl)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene

Conditions	Yield
With triethylamine In dichloromethane for 12h;	95%

trifluoracetyl chloride (354-32-5) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → N-trifluoroacetyl-L-phenylalanine (350-09-4)

Conditions	Yield
In trifluoroacetic acid	95%

trifluoracetyl chloride (354-32-5) + hydroxy-2-propanone (116-09-6) → trifluoroacetoxyacetone

Conditions	Yield
at -30℃;	95%

trifluoracetyl chloride (354-32-5) + dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonothioate (61637-95-4) → trifluoro-acetic acid 2,2,2-trichloro-1-(dimethoxy-thiophosphoryl)-ethyl ester

Conditions	Yield
With triethylamine In dichloromethane at -20 - 20℃;	94.7%

trifluoracetyl chloride (354-32-5) + 2-phenyl-5-methoxyltryptamine (151889-10-0) → N-<2-(5-methoxy-2-phenylindol-3-yl)ethyl>trifluoroacetamide

Conditions	Yield
With triethylamine In dichloromethane for 3h; Ambient temperature;	94%
With triethylamine In dichloromethane

trifluoracetyl chloride (354-32-5) + 2-(2-phenyl-1H-indol-3-yl)ethylamine (1217-80-7) → N-<2-(2-phenylindol-3-yl)ethyl>trifluoroacetamide

Conditions	Yield
With triethylamine In dichloromethane for 3h; Ambient temperature;	94%
With triethylamine In dichloromethane

trifluoracetyl chloride (354-32-5) + methyl 2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoate (1217896-33-7) → methyl 2-(4-{(trifluoroacetyl)[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoate (1217896-34-8)

Conditions	Yield
With potassium carbonate In tetrahydrofuran for 4h; Reflux;	94%

trifluoracetyl chloride (354-32-5) + para-methylacetophenone (122-00-9) → 4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione (720-94-5)

Conditions	Yield
Stage #1: para-methylacetophenone With sodium methylate In di-isopropyl ether at 50℃; for 6h; Stage #2: trifluoracetyl chloride In toluene at 40℃; for 2h; Reagent/catalyst; Concentration; Temperature; Solvent;	93%

trifluoracetyl chloride (354-32-5) + ethyl vinyl ether (109-92-2) → 4-ethoxy-1,1,1-trifluoro-3-butene-2-one (59938-06-6, 17129-06-5)

Conditions	Yield
With pyridine In toluene at 0 - 5℃; for 4h; Temperature; Sealed tube;	92.3%
at 0 - 80℃; Product distribution / selectivity; thermolysis;	90.4%
at 10 - 80℃; for 8h; Product distribution / selectivity; Inert atmosphere; Industry scale;	87%
With 2,6-di-tert-butyl-4-methyl-phenol at 0 - 80℃; Product distribution / selectivity; thermolysis;	83%

trifluoracetyl chloride (354-32-5) + 4-benzylpyperidine (31252-42-3) → 1-(trifluoroacetyl)-4-benzylpiperidine (157338-47-1)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h; Acylation;	92%

trifluoracetyl chloride (354-32-5) + 2,2-dimethyl-1,3-dioxolane-4-methanamine (22195-47-7) → N-[((+/-)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-2,2,2-trifluoroacetamide

Conditions	Yield
With triethylamine In dichloromethane Cooling with ice;	92%

Upstream product

• 98-07-7 Benzotrichlorid 
• 76-05-1 trifluoroacetic acid 
• 88099-83-6 1,1,1-trifluoro-2-chloroethylperoxyl radical 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 306-83-2 1,1,1-trifluoro-2,2-dichloroethane 
• 7782-50-5 chlorine 
• 368-44-5 dichloro(fluoro)(phenyl)silane 
• 407-25-0 trifluoroacetic anhydride 
• 102687-65-0 trans-1-chloro-3,3,3-trifluoropropene 
• 1004-47-3 3-chlorotrifluoro-1,2-oxathietane 2,2-dioxide 
• 933-29-9 4-chlorotrifluoro-1,2-oxathietane 2,2-dioxide 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 147703-34-2 C₂HClF₃O 
• 93370-09-3 methanesulphonyltrifluoroacetic anhydride 

Downstream Products

• 771-83-5 1-(5-chloro-[2]thienyl)-2,2,2-trifluoro-ethanone 
• 461-73-4 2-Methyl-2-butyl trifluoroacetate 
• 814-42-6 Trifluor-essigsaeure-(1,1-dimethyl-butylester) 
• 2557-70-2 2-(trifluoroacetyl)pyrrole 
• 507-52-8 2-(trifluoromethyl)-2-propanol 
• 377-07-1 hydroxy-trifluoromethyl-malonic acid diamide 
• 76-05-1 trifluoroacetic acid 
• 677-71-4 hexafluoroacetone hydrate 
• 684-16-2 Hexafluoroacetone 
• 2314-97-8 iodotrifluoromethane 
• 75-89-8 2,2,2-trifluoroethanol 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 354-34-7 trifluoroacetyl fluoride 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 

Relevant articles and documents

PREPARATION OF CF3-COCl : INVESTIGATION OF OPERATING PARAMETERS

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Copper-catalyzed three component C[sbnd]S/C[sbnd]N coupling for the synthesis of trifluorothioacetamides

A copper-catalyzed three component C[sbnd]S/C[sbnd]N coupling reaction of imines with sulfur and CFC-113a was developed. The reaction involves amination and C[dbnd]S double bond formation of CFC-113a, leading to biologically important trifluorothioacetamides. The method features efficient construction of trifluorothioacetyl moiety from cheap sulfur and CFC-113a, and safe disposal for environmentally persistent Freon

Preparation method of trifluoroacetic acid

The invention discloses a preparation method of trifluoroacetic acid. The preparation method comprises the following steps: (1), vaporizing 1,1,1-trifluoro-2-chloroethane and chlorine gas, then enabling the 1,1,1-trifluoro-2-chloroethane and chlorine gas to enter a fixed bed reactor with a catalyst, and performing a gas phase chlorination reaction to synthesize 1,1,1-trifluoro-2,2-dichloroethane;(2), vaporizing the 1,1,1-trifluoro-2,2-dichloroethane and oxygen, then performing an oxidation reaction under the action of a light source to obtain trifluoroacetyl chloride, condensing the unreacted1,1,1-trifluoro-2,2-dichloroethane, and then enabling the unreacted 1,1,1-trifluoro-2,2-dichloroethane to return to the reactor; (3), hydrolyzing the trifluoroacetyl chloride to obtain the trifluoroacetic acid. The preparation method has the advantages of a simple technology, high yield, few three wastes and the like; in addition, by the preparation method, the reaction conversion rate is high, the selectivity is high, the reaction production is continuous, and the safety and the environment friendliness are achieved.