2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate

Base Information

Chemical Name:2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate
CAS No.:916888-58-9
Molecular Formula:C₂₃H₂₄ClNO₅
Molecular Weight:429.9
Hs Code.:

Synonyms:2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate

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Chemical Property of 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate

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Technology Process of 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate

There total 5 articles about 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 618-46-2
m-Chlorobenzoyl chloride

: 190973-17-2
1-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2-hydroxy-4,6-dimethoxyphenyl)ethanone

: 916888-58-9
2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate

Guidance literature:: With pyridine; dmap; at 20 ℃; for 0.75h;
DOI:10.1016/j.bmc.2006.07.060

Reference yield:

: 113225-07-3
1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridine

: 916888-58-9
2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / BF₃*OEt₂ / CH₂Cl₂ / 20 °C

2: 69 percent / 4-(dimethylamino)pyridine; pyridine / 0.75 h / 20 °C

With pyridine; dmap; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/j.bmc.2006.07.060

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 916888-58-9
2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: HCl gas; AcOH

2: BF₃*Et₂O / CH₂Cl₂

3: pyridine

With pyridine; hydrogenchloride; boron trifluoride diethyl etherate; acetic acid; In dichloromethane; 1: Condensation / 2: Acylation / 3: Acylation;
DOI:10.1016/S0960-894X(00)00156-6