1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile

Base Information

• Chemical Name: 1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile
• CAS No.: 1432048-97-9
• Molecular Formula: C₁₂H₇ClF₅N
• Molecular Weight: 295.639
• Mol file: 1432048-97-9.mol

Synonyms:1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile

Chemical Property of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile

There total 3 articles about 1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-oxocyclobutanecarbonitrile (1432048-96-8) → 1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile (1432048-97-9)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃;

Reference yield:

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile (1432048-95-7) → 1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile (1432048-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 20 °C

With diethylamino-sulfur trifluoride; sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane;

Reference yield:

2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile (22902-82-5) → 1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile (1432048-97-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diethyl ether; tetrahydrofuran / 1 h / -78 °C

1.2: 1.5 h / -78 °C

1.3: -78 - 20 °C

2.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 20 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C

With diethylamino-sulfur trifluoride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane;

upstream raw materials:

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile

2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-oxocyclobutanecarbonitrile

Downstream raw materials:

{1-[4-chloro-3-(trifluoromethyl)phenyl]-3,3-difluorocyclobutyl}(pyridin-2-yl)methanol

(1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutyl)(pyridin-2-yl)methanone