1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile

Base Information

• Chemical Name: 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile
• CAS No.: 1432048-95-7
• Molecular Formula: C₁₂H₉ClF₃NO
• Molecular Weight: 275.658
• Mol file: 1432048-95-7.mol

Synonyms:1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile

Chemical Property of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile

There total 2 articles about 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile (22902-82-5) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile (1432048-95-7)

Guidance literature:

2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile; With methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

1,2-Epoxy-3-bromopropane; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.5h;

With methyl magnesium iodide; In tetrahydrofuran; diethyl ether; at 20 ℃;

Reference yield: 74.2%

methyl magnesium iodide (917-64-6) + 2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile (22902-82-5) + methyllithium (917-54-4) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile (1432048-95-7)

Guidance literature:

2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

1,2-Epoxy-3-bromopropane; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.5h;

methyl magnesium iodide; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

Reference yield:

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy cyclobutanecarbonitrile (1432048-95-7) → {1-[4-chloro-3-(trifluoromethyl)phenyl]-3,3-difluorocyclobutyl}(pyridin-2-yl)methanol (1432048-94-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C

3.1: hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 0.75 h / -78 °C

4.1: methanol; sodium tetrahydroborate / 1 h / 20 °C

With methanol; sodium tetrahydroborate; diethylamino-sulfur trifluoride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

methyl magnesium iodide

2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile

methyllithium

1,2-Epoxy-3-bromopropane

Downstream raw materials:

{1-[4-chloro-3-(trifluoromethyl)phenyl]-3,3-difluorocyclobutyl}(pyridin-2-yl)methanol

1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutanecarbonitrile

(1-(4-chloro-3-(trifluoromethyl)phenyl)-3,3-difluorocyclobutyl)(pyridin-2-yl)methanone