2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester

Base Information

• Chemical Name: 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester
• CAS No.: 960398-41-8
• Molecular Formula: C₃₉H₄₆N₂O₆
• Molecular Weight: 638.804
• Mol file: 960398-41-8.mol

Synonyms:2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester

Chemical Property of 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester

There total 9 articles about 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

(4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester (960398-40-7) + 2-benzyloxy-5-(R)-oxiranylbenzoic acid methyl ester (94749-70-9) → 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester (960398-41-8) + C56H62N2O10 (960398-79-2)

Guidance literature:

In ethanol; at 60 ℃; for 48h;

Reference yield:

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)but-1-ynyl)phenyl)but-3-ynyl)carbamic acid benzyl ester → 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester (960398-41-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 24 h / 20 °C / 2327.23 Torr

2: hydrazine / ethanol; dichloromethane / 16 h / Heating / reflux

3: ethanol / 48 h / 60 °C

With hydrogen; hydrazine; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

N-benzyloxycarbonyl-but-3-ynyl-1-amine (149965-78-6) → 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester (960398-41-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 24 h / 20 °C / 2327.23 Torr

3.1: hydrazine / ethanol; dichloromethane / 16 h / Heating / reflux

4.1: ethanol / 48 h / 60 °C

With copper(l) iodide; hydrogen; triethylamine; hydrazine; bis-triphenylphosphine-palladium(II) chloride; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

(4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester

2-benzyloxy-5-(R)-oxiranylbenzoic acid methyl ester

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyl)phenyl)butyl)carbamic acid benzyl ester

estere metilico dell'acido 5-acetilsalicilico

Downstream raw materials:

(4-(4-(4-(2-(4-benzyloxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethylamino)butyl)phenyl)butyl)carbamic acid benzyl ester

4-(2-(4-(4-(4-aminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)-2-hydroxymethylphenol