(+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine

Base Information

• Chemical Name: (+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine
• CAS No.: 102852-52-8
• Molecular Formula: C₂₇H₄₂N₂O₄
• Molecular Weight: 458.641

Synonyms:(+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine

Chemical Property of (+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine

There total 2 articles about (+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Verapamil (52-53-9,56949-77-0) → (+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine (102852-52-8)

Guidance literature:

Verapamil; With lithium aluminium tetrahydride; In tetrahydrofuran; for 10h; Reflux;

With water; potassium hydroxide; In tetrahydrofuran; diethyl ether; at 0 ℃;

Reference yield:

verapamil hydrochloride (23313-68-0,152-11-4) → (+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine (102852-52-8)

Guidance literature:

With sodium hydroxide; lithium aluminium tetrahydride; Yield given. Multistep reaction; 1.) THF, reflux, 12 h, 2.) THF, water, RT, 30 min;

DOI:10.1021/jm00159a040

Reference yield: 68.0%

2,2,5,5-tetramethyl-pyrrolidinyl-1-oxyl-3-carboxylic acid chloride (13810-21-4) + (+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentylamine (102852-52-8) → 1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-carboxylic acid [(2-(3,4-dimethoxy-phenyl))-5-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-isopropyl]-pentylamide radical (1228254-11-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2010.02.040

upstream raw materials:

verapamil hydrochloride

Verapamil

Downstream raw materials:

(+/-)-5-<(3,4-dimethoxyphenethyl)methylamino>-2-(3,4-dimethoxyphenyl)-2-isopropylpentyl isothiocyanate

1,2,2,5,5-pentamethyl-2,5-dihydro-1H-pyrrol-3-carboxylicacid-[(2-(3,4-dimethoxy-phenyl))-5-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-isopropyl]-pentylamide

1-oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid [(2-(3,4-dimethoxyphenyl))-5-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-isopropyl]-pentylamide radical

1-oxyl-2,2,6,6-tetramethyl-piperidine-4-carboxylic acid[(2-(3,4-dimethoxyphenyl))-5-[[2-(3,4-dimethoxyphenyl)-ethyl]methylamino]-2-isopropyl]-pentylamide radical

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