Technology Process of 4-cyclopentyl-3-(trifluoromethyl)benzaldehyde
There total 5 articles about 4-cyclopentyl-3-(trifluoromethyl)benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-bromo-1-cyclopentyl-2-(trifluoromethyl)benzene;
With
n-butyllithium;
In
tetrahydrofuran; hexanes;
at -78 ℃;
Inert atmosphere;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexanes;
at -78 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N,N,-tetramethylethylenediamine; magnesium / iron(III) chloride / tetrahydrofuran / 20 - 30 °C / Inert atmosphere
2.1: bromine; sulfuric acid; acetic acid / 1.5 h / 40 °C
3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.42 h / -78 °C / Cooling with IPA-dry ice; Inert atmosphere
3.2: 0.83 h / -78 - 20 °C / Cooling with IPA-dry ice; Inert atmosphere
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; bromine; magnesium; acetic acid;
iron(III) chloride;
In
tetrahydrofuran; hexanes;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / -78 °C / Cooling with IPA-dry ice; Inert atmosphere
1.2: 1.5 h / -78 - 20 °C / Cooling with IPA-dry ice; Inert atmosphere
1.3: pH 4 - 5 / Cooling with ice
2.1: hydrogen / palladium 10% on activated carbon / ethanol
3.1: bromine; sulfuric acid; acetic acid / 1.5 h / 40 °C
4.1: n-butyllithium / tetrahydrofuran; hexanes / 0.42 h / -78 °C / Cooling with IPA-dry ice; Inert atmosphere
4.2: 0.83 h / -78 - 20 °C / Cooling with IPA-dry ice; Inert atmosphere
With
n-butyllithium; sulfuric acid; hydrogen; bromine; acetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; hexanes; ethanol;
