(R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Base Information

Chemical Name:(R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate
CAS No.:1206124-34-6
Molecular Formula:C₂₈H₃₀F₃NO₃
Molecular Weight:485.546
Hs Code.:

Synonyms:(R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Suppliers and Price of (R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 8 raw suppliers

Chemical Property of (R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

There total 20 articles about (R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 957208-65-0
4-(chloromethyl)-1-cyclopentyl-2-(trifluoromethyl)benzene

: 1206124-13-1
ethyl 2-(7-hydroxy-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

: 1206124-34-6
(R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Guidance literature:: With caesium carbonate; In acetonitrile; at 40 - 65 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 392-83-6
o-trifluoromethylphenyl bromide

: 1206124-34-6
(R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N,N,N,-tetramethylethylenediamine; magnesium / iron(III) chloride / tetrahydrofuran / 20 - 30 °C / Inert atmosphere

2: thionyl chloride; sulfuric acid / -5 - 20 °C / Inert atmosphere

3: caesium carbonate / acetonitrile / 40 - 65 °C / Inert atmosphere

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; caesium carbonate; magnesium; iron(III) chloride; In tetrahydrofuran; acetonitrile;

Reference yield:

: 120-92-3
cyclopentanone

: 1206124-34-6
(R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / -78 °C / Cooling with IPA-dry ice; Inert atmosphere

1.2: 1.5 h / -78 - 20 °C / Cooling with IPA-dry ice; Inert atmosphere

1.3: pH 4 - 5 / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / ethanol

3.1: thionyl chloride; sulfuric acid / -5 - 20 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 40 - 65 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; sulfuric acid; hydrogen; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; hexanes; ethanol; acetonitrile;